Radiation Pneumonitis: Old Problem, New Tricks

被引：112
作者：
Jain, Varsha [1 ]
Berman, Abigail T. [1 ]
机构：
[1] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA
来源：
CANCERS | 2018年 / 10卷 / 07期
关键词：
radiation pneumonitis; radiation therapy; lung cancer; CELL LUNG-CANCER; COMPUTED-TOMOGRAPHY VENTILATION; PULMONARY-FUNCTION; INTERSTITIAL PNEUMONITIS; BRONCHOALVEOLAR LAVAGE; SUPEROXIDE-DISMUTASE; RESPONSE CRITERIA; HEART IRRADIATION; MESSENGER-RNA; STAGE-I;
D O I：
10.3390/cancers10070222
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Radiation therapy is a major treatment modality for management of non-small cell lung cancer. Radiation pneumonitis is a dose limiting toxicity of radiotherapy, affecting its therapeutic ratio. This review presents patient and treatment related factors associated with the development of radiation pneumonitis. Research focusing on reducing the incidence of radiation pneumonitis by using information about lung ventilation, imaging-based biomarkers as well as normal tissue complication models is discussed. Recent advances in our understanding of molecular mechanisms underlying lung injury has led to the development of several targeted interventions, which are also explored in this review.
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页数：16
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