Cytotoxic urea Schiff base complexes for multidrug discovery as anticancer activity and low in vivo oral assessing toxicity

被引：16
作者：
Aroua, Lotfi M. [1 ,2 ,3 ]
Al-Hakimi, Ahmed N. [1 ,4 ]
Abdulghani, Mahfoudh A. M. [5 ]
Alhag, Sadeq K. [6 ]
机构：
[1] Qassim Univ, Coll Sci, Dept Chem, Campus Univ,King Abdulaziz Rd,Al Malida,POB 6644, Buraydah 51452, Qassim, Saudi Arabia
[2] Tunis El Manar Univ, Fac Sci Tunis, Dept Chem, Lab Organ Struct Chem & Macromol, Tunis 2092, Tunisia
[3] Carthage Univ, Fac Sci Bizerte, Dept Chem, Jarzouna 7021, Tunisia
[4] Ibb Univ, Fac Sci, Dept Chem, Ibb, Yemen
[5] Qassim Univ, Unaizah Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 5919, Qassim, Saudi Arabia
[6] King Khalid Univ, Coll Sci & Arts, Biol Dept, Muhayl Asser, Saudi Arabia
来源：
ARABIAN JOURNAL OF CHEMISTRY | 2022年 / 15卷 / 08期
关键词：
Anticancer activity; Complex; Urea; Schiff base; Low in vivo assessing toxicity; COPPER(II) COMPLEX; CRYSTAL-STRUCTURE; METAL-COMPLEXES; DNA-BINDING; CU(II); AGENTS; DERIVATIVES; LIGAND; CANCER; VITRO;
D O I：
10.1016/j.arabjc.2022.103986
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel mononuclear complexes 2-8 derived from hybrid Urea Schiff base HL were synthesized using various metal Ni2+, Fe3+, Cu2+, Co2+, Mn2+, Zn2+, and Cr3+. The results revealed the ligand HL reacts with metal ions as monobasic or neutral monodentate chelator it via the nitrogen of azomethine and deprotonated/protonated phenolic oxygen atom adopting octahedral geometry. The elemental analysis of the complexes showed the bonding of the ligand with the metal ions in a ratio of 1:1 in all-metal complexes. XRD analysis of the ligand and its complexes indicate a monoclinic, tetragonal, orthorhombic corresponding to urea Shiff base (1) and zinc complex (7), nickel complex (2), and cobalt complexes (5), respectively. The bioactivity of synthesized compounds was tested and screened against three cancer cell lines PC3 (prostate), SK-OV-3 (ovarian), and HeLa (cervical). The results revealed a weak activity for the ligand, whereas nickel and iron complexes present moderate activities against three cancer cells. The best results were mentioned with copper and proved the best results against three cancer cells PC3, SKOV3, and HeLa displaying an excellent activity with IC50 values of 0.71 +/- 0.06, 0.12 +/- 0.06, and 0.79 +/- 0.23 lg/ mL respectively. Moreover, the urea Schiff base complexes showed good safety in vivo toxicity test. The present study demonstrates that all urea Schiff base complexes is inactive against saint tissue and five metal complexes investigated herein can be effective and promising chemotherapeutic drugs for ovarian cancer cell SKOV3, emphasizing the copper-urea Schiff base complex. (C) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
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页数：18
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