The risk of recurrent venous thromboembolism among patients with high factor IX levels

被引：74

作者：

Weltermann, A

Eichinger, S

Bialonczyk, C

Minar, E

Hirschl, M

Quehenberger, P

Schönauer, V

Kyrle, PA

机构：

[1] Univ Hosp Vienna, Div Hematol & Hemostatis, Dept Internal Med 1, Vienna, Austria

[2] Univ Hosp Vienna, Dept Internal Med 2, Div Angiol, Vienna, Austria

[3] Univ Hosp Vienna, Inst Clin Med, Vienna, Austria

[4] Univ Hosp Vienna, Chem Lab Diagnost, Vienna, Austria

[5] Wilhelminenspital Stadt Wien, Dept Dermatol, Vienna, Austria

[6] Hanuschkrankenhaus, Dept Angiol, Vienna, Austria

[7] Ludwig Boltzmann Inst Thrombosis Res, Vienna, Austria

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2003年 / 1卷 / 01期

关键词：

factor IX; factor VIII; venous thrombosis; recurrence;

D O I：

10.1046/j.1538-7836.2003.00038.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High factor IX (FIX) is a risk factor of deep vein thrombosis. The impact of high FIX on the risk of recurrent venous thrombosis is unknown. We prospectively followed 546 patients after anticoagulation for a first spontaneous venous thromboembolism. Patients with a natural coagulation inhibitor deficiency, lupus anticoagulant or cancer were excluded. At 3 years, the likelihood of recurrence was 23% among patients with high FIX (exceeding the 75th percentile) compared with 11% among patients with lower levels. Among patients with high FIX, the relative risk of recurrence was 2.2 (95% Cl: 1.3-3.6) before and was 1.6 (95% Cl: 1.0-2.8) after adjustment for age, gender, duration of anticoagulation, FV Leiden, FII G20210A, high FVIII and hyperhomocysteinemia. Compared with patients with low factor IX (< 138 IU dL(-1)) and low FVIII (< 234 IU dL(-1)), the relative risk of recurrence was 1.5 among patients with high FIX and low FVIII, 2.7 among patients with low FIX and high FVIII and 6.6 among patients with high FIX and high FVIII. High levels of FIX confer an increased risk of recurrent venous thromboembolism and enhance the risk of recurrence among patients with high FVIII.

引用

页码：28 / 32

页数：5

共 34 条

[21]

ODonnell J, 1997, THROMB HAEMOSTASIS, V77, P825

[22]

Oger E, 2000, THROMB HAEMOSTASIS, V83, P657

[23] HEREDITARY-DEFICIENCY OF ANTITHROMBIN-III, PROTEIN-C AND PROTEIN-S - PREVALENCE IN PATIENTS WITH A HISTORY OF VENOUS THROMBOSIS AND CRITERIA FOR RATIONAL PATIENT SCREENING [J].

PABINGER, I ;

BRUCKER, S ;

KYRLE, PA ;

SCHNEIDER, B ;

KORNINGER, HC ;

NIESSNER, H ;

LECHNER, K .

BLOOD COAGULATION & FIBRINOLYSIS, 1992, 3 (05) :547-553

[24] Bleeding complications of oral anticoagulant treatment: An inception-cohort, prospective collaborative study (ISCOAT) [J].

Palareti, G ;

Leali, N ;

Coccheri, S ;

Poggi, M ;

Manotti, C ;

DAngelo, A ;

Pengo, V ;

Erba, N ;

Moia, M ;

Ciavarella, N ;

Devote, G ;

Berrettini, M ;

Musolesi, S .

LANCET, 1996, 348 (9025) :423-428

[25] A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis [J].

Poort, SR ;

Rosendaal, FR ;

Reitsma, PH ;

Bertina, RM .

BLOOD, 1996, 88 (10) :3698-3703

[26] The long-term clinical course of acute deep venous thrombosis [J].

Prandoni, P ;

Lensing, AWA ;

Cogo, A ;

Cuppini, S ;

Villalta, S ;

Carta, M ;

Cattelan, AM ;

Polistena, P ;

Bernardi, E ;

Prins, MH .

ANNALS OF INTERNAL MEDICINE, 1996, 125 (01) :1-+

[27]

Ridker PM, 1997, CIRCULATION, V95, P1777

[28] Venous thrombosis: a multicausal disease [J].

Rosendaal, FR .

LANCET, 1999, 353 (9159) :1167-1173

[29] The duration of oral anticoagulant therapy after a second episode of venous thromboembolism [J].

Schulman, S ;

Granqvist, S ;

Holmstrom, M ;

Carlsson, A ;

Lindmarker, P ;

Nicol, P ;

Eklund, SG ;

Nordlander, S ;

Larfars, G ;

Leijd, B ;

Linder, O ;

Loogna, E ;

Gustafsson, C ;

Grondahl, A ;

Rhedin, AS ;

Tornebohm, E ;

Lockner, D ;

Johnsson, H ;

Kobosko, J ;

Malmros, B ;

Arcini, N ;

Saaw, J ;

Stig, R ;

Viering, S ;

Ljungberg, B ;

Wilhelmsson, S ;

Ohlsson, A ;

Walter, H ;

Malmqvist, K ;

AlKhalili, F ;

Petrescu, A ;

Brohult, J ;

Hulting, J ;

Svensson, E ;

Dahlin, L ;

Boberg, J ;

Marjanovics, B ;

Jonsson, KA ;

Malm, C ;

Hjorth, M ;

Lindgren, A ;

Fagrell, B ;

Kallner, M ;

Wadman, B ;

Snyder, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (06) :393-398

[30] Recurrence of venous thromboembolism in patients with familial thrombophilia [J].

vandenBelt, AGM ;

Sanson, BJ ;

Simioni, P ;

Prandoni, P ;

Buller, HR ;

Girolami, A ;

Prins, MH .

ARCHIVES OF INTERNAL MEDICINE, 1997, 157 (19) :2227-2232

← 1 2 3 4 →