Ensembl 2005

被引:359
作者
Hubbard, T
Andrews, D
Caccamo, M
Cameron, G
Chen, Y
Clamp, M
Clarke, L
Coates, G
Cox, T
Cunningham, F
Curwen, V
Cutts, T
Down, T
Durbin, R
Fernandez-Suarez, XM
Gilbert, J
Hammond, M
Herrero, J
Hotz, H
Howe, K
Iyer, V
Jekosch, K
Kahari, A
Kasprzyk, A
Keefe, D
Keenan, S
Kokocinsci, F
London, D
Longden, I
McVicker, G
Melsopp, C
Meidl, P
Potter, S
Proctor, G
Rae, M
Rios, D
Schuster, M
Searle, S
Severin, J
Slater, G
Smedley, D
Smith, J
Spooner, W
Stabenau, A
Stalker, J
Storey, R
Trevanion, S
Ureta-Vidal, A
Vogel, J
White, S
机构
[1] EMBL, European Bioinformat Inst, Hinxton CB10 1SA, Cambs, England
[2] Wellcome Trust Res Labs, Sanger Inst, Hinxton CB10 1SA, Cambs, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1093/nar/gki138
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Ensembl (http://www.ensembi.org/) project provides a comprehensive and integrated source of annotation of large genome sequences. Over the last year the number of genomes available from the Ensembl site has increased by 7 to 16, with the addition of the six vertebrate genomes of chimpanzee,dog, cow, chicken, tetraodon and frog and the insect genome of honeybee. The majority have been annotated automatically using the Ensembl gene build system, showing its flexibility to reliably annotate a wide variety of genomes. With the increased number of vertebrate genomes, the comparative analysis provided to users has been greatly improved, with new website interfaces allowing annotation of different genomes to be directly compared. The Ensembl software system is being increasingly widely reused in different projects showing the benefits of a completely open approach to software development and distribution.
引用
收藏
页码:D447 / D453
页数:7
相关论文
共 29 条
[1]   The Vertebrate Genome Annotation (Vega) database [J].
Ashurst, JL ;
Chen, CK ;
Gilbert, JGR ;
Jekosch, K ;
Keenan, S ;
Meidl, P ;
Searle, SM ;
Stalker, J ;
Storey, R ;
Trevanion, S ;
Wilming, L ;
Hubbard, T .
NUCLEIC ACIDS RESEARCH, 2005, 33 :D459-D465
[2]   Gene annotation: Prediction and testing [J].
Ashurst, JL ;
Collins, JE .
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2003, 4 :69-88
[3]   GeneWise and genomewise [J].
Birney, E ;
Clamp, M ;
Durbin, R .
GENOME RESEARCH, 2004, 14 (05) :988-995
[4]   An overview of ensembl [J].
Birney, E ;
Andrews, TD ;
Bevan, P ;
Caccamo, M ;
Chen, Y ;
Clarke, L ;
Coates, G ;
Cuff, J ;
Curwen, V ;
Cutts, T ;
Down, T ;
Eyras, E ;
Fernandez-Suarez, XM ;
Gane, P ;
Gibbins, B ;
Gilbert, J ;
Hammond, M ;
Hotz, HR ;
Iyer, V ;
Jekosch, K ;
Kahari, A ;
Kasprzyk, A ;
Keefe, D ;
Keenan, S ;
Lehvaslaiho, H ;
McVicker, G ;
Melsopp, C ;
Meidl, P ;
Mongin, E ;
Pettett, R ;
Potter, S ;
Proctor, G ;
Rae, M ;
Searle, S ;
Slater, G ;
Smedley, D ;
Smith, J ;
Spooner, W ;
Stabenau, A ;
Stalker, J ;
Storey, R ;
Ureta-Vidal, A ;
Woodwark, KC ;
Cameron, G ;
Durbin, R ;
Cox, A ;
Hubbard, T ;
Clamp, M .
GENOME RESEARCH, 2004, 14 (05) :925-928
[5]   Ensembl 2004 [J].
Birney, E ;
Andrews, D ;
Bevan, P ;
Caccamo, M ;
Cameron, G ;
Chen, Y ;
Clarke, L ;
Coates, G ;
Cox, T ;
Cuff, J ;
Curwen, V ;
Cutts, T ;
Down, T ;
Durbin, R ;
Eyras, E ;
Fernandez-Suarez, XM ;
Gane, P ;
Gibbins, B ;
Gilbert, J ;
Hammond, M ;
Hotz, H ;
Iyer, V ;
Kahari, A ;
Jekosch, K ;
Kasprzyk, A ;
Keefe, D ;
Keenan, S ;
Lehvaslaiho, H ;
McVicker, G ;
Melsopp, C ;
Meidl, P ;
Mongin, E ;
Pettett, R ;
Potter, S ;
Proctor, G ;
Rae, M ;
Searle, S ;
Slater, G ;
Smedley, D ;
Smith, J ;
Spooner, W ;
Stabenau, A ;
Stalker, J ;
Storey, R ;
Ureta-Vidal, A ;
Woodwark, C ;
Clamp, M ;
Hubbard, T .
NUCLEIC ACIDS RESEARCH, 2004, 32 :D468-D470
[6]   Finishing the euchromatic sequence of the human genome [J].
Collins, FS ;
Lander, ES ;
Rogers, J ;
Waterston, RH .
NATURE, 2004, 431 (7011) :931-945
[7]   The Ensembl computing architecture [J].
Cuff, JA ;
Coates, GMP ;
Cutts, TJR ;
Rae, M .
GENOME RESEARCH, 2004, 14 (05) :971-975
[8]   The Ensembl automatic gene annotation system [J].
Curwen, V ;
Eyras, E ;
Andrews, TD ;
Clarke, L ;
Mongin, E ;
Searle, SMJ ;
Clamp, M .
GENOME RESEARCH, 2004, 14 (05) :942-950
[9]   The Distributed Annotation System [J].
Dowell, Robin D. ;
Jokerst, Rodney M. ;
Day, Allen ;
Eddy, Sean R. ;
Stein, Lincoln .
BMC BIOINFORMATICS, 2001, 2 (1)
[10]   ESTGenes: Alternative splicing from ESTs in Ensembl [J].
Eyras, E ;
Caccamo, M ;
Curwen, V ;
Clamp, M .
GENOME RESEARCH, 2004, 14 (05) :976-987