Intraductal Papillary Mucinous Neoplasms of the Pancreas: Current Understanding and Future Directions for Stratification of Malignancy Risk

被引：29

作者：

Fonseca, Annabelle L. ^{[1
]}

Kirkwood, Kimberly ^{[2
]}

Kim, Michael P. ^{[1
]}

Maitra, Anirban ^{[3
]}

Koay, Eugene J. ^{[4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, 1400 Pressler St,Unit 1484, Houston, TX 77030 USA

[2] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol & Translat Mol Pathol, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

来源：

PANCREAS | 2018年 / 47卷 / 03期

基金：

美国国家卫生研究院;

关键词：

IPMN; risk of malignancy; pancreatic mucinous neoplasms; management of IPMNs; INTERNATIONAL CONSENSUS GUIDELINES; PREDICTORS; MANAGEMENT; DIAGNOSIS; BIOMARKERS; GNAS; KRAS; MUTATIONS; MICRORNAS; CLASSIFICATION;

D O I：

10.1097/MPA.0000000000000999

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The incidence of intraductal papillary mucinous neoplasms (IPMNs) has been increasing over the past decade, mainly owing to increased awareness and the increased use of cross-sectional imaging. The Sendai and Fukuoka consensus guidelines provide us with clinical management guidelines and algorithms; however, the clinical management of IPMNs continues to be challenging. Our incomplete understanding of the natural history of the disease, and the events and pathways that permit progression to adenocarcinoma, result in difficulties predicting which tumors are high risk and will progress to invasive disease. In this review, we summarize the current management guidelines and describe ongoing efforts to more clearly stratify IPMNs by risk of malignancy and identify IPMNs with malignant potential or ongoing malignant transformation.

引用

页码：272 / 279

页数：8

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