Applications of CRISPR technologies in transplantation

被引：19
作者：
Kuscu, Cem [1 ]
Kuscu, Canan [1 ]
Bajwa, Amandeep [1 ]
Eason, James D. [1 ]
Maluf, Daniel [1 ]
Mas, Valeria R. [1 ]
机构：
[1] Univ Tennessee, Hlth Sci Ctr, James D Eason Transplant Inst, Transplant Res Inst,Sch Med,Dept Surg, Memphis, TN 38163 USA
来源：
AMERICAN JOURNAL OF TRANSPLANTATION | 2020年 / 20卷 / 12期
关键词：
basic (laboratory) research; science; translational research; molecular biology; xenotransplantation; immunosuppression; immune modulation; animal models; porcine; genomics; tolerance; chimerism; xenoantigen; GENOMIC DNA; RNA; CELLS; CAS9; NUCLEASES; MOUSE; BASE; GENE; ENDONUCLEASE; GENERATION;
D O I：
10.1111/ajt.16095
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
In transplantation, the ever-increasing number of an organ's demand and long-term graft dysfunction constitute some of the major problems. Therefore, alternative solutions to increase the quantity and quality of the organ supply for transplantation are desired. On this subject, revolutionary Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology holds enormous potential for the scientific community with its expanding toolbox. In this minireview, we summarize the history and mechanism of CRISPR/Cas9 systems and explore its potential applications in cellular- and organ-level transplantation. The last part of this review includes future opportunities as well as the challenges in the transplantation field.
引用
收藏
页码：3285 / 3293
页数：9
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