Histone methylation marks play important roles in predicting the methylation status of CpG islands

被引：43

作者：

Fan, Shicai ^{[1
,2
,3
]}

Zhang, Michael Q. ^{[1
,2
,4
]}

Zhang, Xuegong ^{[1
,2
]}

机构：

[1] Tsinghua Univ, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Bioinformat Div, TNLIST Dept Automat, Beijing 100084, Peoples R China

[3] Univ Elect Sci & Technol China, Sch Automat Engn, Chengdu 610054, Peoples R China

[4] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11274 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 374卷 / 03期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

DNA methylation; CpG island; histone methylation; epigenetics;

D O I：

10.1016/j.bbrc.2008.07.077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The methylation status of CpG islands is highly correlated with gene expression. Current methods for computational prediction of DNA methylation only utilize DNA sequence features. In this study, besides 35 DNA sequence features, we added four histone methylation marks to predict the methylation status of CpG islands, and improved the accuracy to 89.94%. Also we applied our model to predict the methylation pattern of all the CpG islands in the human genome, and the results are consistent with the previous reports. Our results imply the important roles of histone methylation marks in affecting the methylation status of CpG islands. H3K4me enriched in the methylation-resistant CpG islands could disrupt the contacts between nucleosomes, unravel chromatin and make DNA sequences accessible. And the established open environment may be a prerequisite for or a consequence of the function implementation of zinc finger proteins that could protect CpG islands from DNA methylation. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：559 / 564

页数：6

共 35 条

[1] High-resolution profiling of histone methylations in the human genome [J].