Programmable Self-Assembly of Antibody-Oligonucleotide Conjugates as Small Molecule and Protein Carriers

被引：13
|
作者：
Gangar, Amit [1 ,2 ]
Fegan, Adrian [1 ,2 ]
Kumarapperuma, Sidath C. [1 ]
Wagner, Carston R. [1 ]
机构：
[1] Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 06期
基金：
美国国家卫生研究院;
关键词：
TARGETED CANCER-THERAPY; EPIDERMAL-GROWTH-FACTOR; IMMUNOTOXINS; RECEPTORS; ENTRY;
D O I：
10.1021/ja210894g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.
引用
收藏
页码：2895 / 2897
页数：3
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