Programmable Self-Assembly of Antibody-Oligonucleotide Conjugates as Small Molecule and Protein Carriers

被引：13
|
作者：
Gangar, Amit [1 ,2 ]
Fegan, Adrian [1 ,2 ]
Kumarapperuma, Sidath C. [1 ]
Wagner, Carston R. [1 ]
机构：
[1] Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 06期
基金：
美国国家卫生研究院;
关键词：
TARGETED CANCER-THERAPY; EPIDERMAL-GROWTH-FACTOR; IMMUNOTOXINS; RECEPTORS; ENTRY;
D O I：
10.1021/ja210894g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.
引用
收藏
页码：2895 / 2897
页数：3
相关论文
共 50 条
  • [1] Antibody-oligonucleotide conjugates enter the clinic
    Mullard, Asher
    NATURE REVIEWS DRUG DISCOVERY, 2022, 21 (01) : 6 - 8
  • [2] Antibody-Oligonucleotide Conjugates: A Twist to Antibody-Drug Conjugates
    Dugal-Tessier, Julien
    Thirumalairajan, Srinath
    Jain, Nareshkumar
    JOURNAL OF CLINICAL MEDICINE, 2021, 10 (04) : 1 - 17
  • [3] Antibody-Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents
    Dovgan, Igor
    Koniev, Oleksandr
    Kolodych, Sergii
    Wagner, Alain
    BIOCONJUGATE CHEMISTRY, 2019, 30 (10) : 2483 - 2501
  • [4] An Approach to Multiplexing an Immunosorbent Assay with Antibody-Oligonucleotide Conjugates
    Han, Ki-Cheol
    Ahn, Dae-Ro
    Yang, Eun Gyeong
    BIOCONJUGATE CHEMISTRY, 2010, 21 (12) : 2190 - 2196
  • [5] Synthesis and self-assembly of perylenediimide-oligonucleotide conjugates
    Abdalla, MA
    Bayer, J
    Rädler, JO
    Müllen, K
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (30) : 3967 - 3970
  • [6] Self-Assembled Antibody-Oligonucleotide Conjugates for Targeted Delivery of Complementary Antisense Oligonucleotides
    Zhou, Liujuan
    Bi, Jie
    Chang, Shenghai
    Bai, Zhaoshuai
    Yu, Junqi
    Wang, Ruru
    Li, Zhihang
    Zhang, Xing
    Chou, James J.
    Pan, Liqiang
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 64 (03)
  • [7] Non-specific interactions of antibody-oligonucleotide conjugates with living cells
    Victor Lehot
    Isabelle Kuhn
    Marc Nothisen
    Stéphane Erb
    Sergii Kolodych
    Sarah Cianférani
    Guilhem Chaubet
    Alain Wagner
    Scientific Reports, 11
  • [8] Non-specific interactions of antibody-oligonucleotide conjugates with living cells
    Lehot, Victor
    Kuhn, Isabelle
    Nothisen, Marc
    Erb, Stephane
    Kolodych, Sergii
    Cianferani, Sarah
    Chaubet, Guilhem
    Wagner, Alain
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [9] Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs)
    Malecova, Barbora
    Burke, Rob S.
    Cochran, Michael
    Hood, Michael D.
    Johns, Rachel
    Kovach, Philip R.
    Doppalapudi, Venkata R.
    Erdogan, Gulin
    Arias, J. Danny
    Darimont, Beatrice
    Miller, Christopher D.
    Huang, Hanhua
    Geall, Andrew
    Younis, Husam S.
    Levin, Arthur A.
    NUCLEIC ACIDS RESEARCH, 2023, 51 (12) : 5901 - 5910
  • [10] Programmable self-assembly
    Cademartiri, Ludovico
    Bishop, Kyle J. M.
    NATURE MATERIALS, 2015, 14 (01) : 2 - 9
12345