Programmable Self-Assembly of Antibody-Oligonucleotide Conjugates as Small Molecule and Protein Carriers

被引：13

作者：

Gangar, Amit ^{[1
,2
]}

Fegan, Adrian ^{[1
,2
]}

Kumarapperuma, Sidath C. ^{[1
]}

Wagner, Carston R. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 06期

基金：

美国国家卫生研究院;

关键词：

TARGETED CANCER-THERAPY; EPIDERMAL-GROWTH-FACTOR; IMMUNOTOXINS; RECEPTORS; ENTRY;

D O I：

10.1021/ja210894g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.

引用

页码：2895 / 2897

页数：3

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