The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

被引：2507

作者：

Grakoui, Arash ^{[1
,2
]}

Bromley, Shannon K. ^{[1
,2
]}

Sumen, Cenk ^{[3
]}

Davis, Mark M. ^{[3
]}

Shaw, Andrey S. ^{[1
,2
]}

Allen, Paul M. ^{[1
,2
]}

Dustin, Michael L. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA

[3] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

JOURNAL OF IMMUNOLOGY | 2015年 / 194卷 / 09期

基金：

英国惠康基金;

关键词：

II PEPTIDE COMPLEXES; LIPID-LINKED FORM; ANTIGEN-RECEPTOR; SIGNAL-TRANSDUCTION; POSITIVE SELECTION; ANTAGONIST LIGANDS; PLANAR BILAYERS; ADHESION; RECOGNITION; MEMBRANES;

D O I：

10.1126/science.285.5425.221

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central duster was dependent on T cell receptor-liigand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation.

引用

页码：221 / 227

页数：7

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