A Sensitive Sensor for Nano-Molar Detection of 5-Fluorouracil by Modifying a Paste Sensor with Graphene Quantum Dots and an Ionic Liquid

被引：12
作者：
Emamian, Reyhane [1 ]
Ebrahimi, Mahmond [1 ]
Karimi-Maleh, Hassan [2 ,3 ,4 ]
机构：
[1] Islamic Azad Univ, Dept Chem, Mashhad Branch, Mashhad, Razavi Khorasan, Iran
[2] Quchan Univ Technol, Dept Chem Engn, Lab Nanotechnol, Quchan, Iran
[3] Univ Johannesburg, Dept Appl Chem, ZA-17011 Johannesburg, South Africa
[4] Univ Elect Sci & Technol China, Sch Resources & Environm, Xiyuan Ave, Chengdu, Peoples R China
来源：
JOURNAL OF NANOSTRUCTURES | 2020年 / 10卷 / 02期
关键词：
I-Butylpyridinium bromide; 5-Fluorouracil; Electrochemical sensor; Graphene quantum dot; Sensor; MOLECULARLY IMPRINTED POLYMER; ANTICANCER DRUG 5-FLUOROURACIL; ELECTROCHEMICAL SENSOR; VOLTAMMETRIC DETERMINATION; CARBON NANOTUBES; AMPLIFIED SENSOR; VITAMIN-C; ELECTRODE; BIOSENSOR; NANOPARTICLES;
D O I：
10.22052/JNS.2020.02.004
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
5-fluorouracil is a widely used anticancer drug with many side effects on humans, and hence its analysis in biological samples is very important. Accordingly, a novel sensitive electrochemical approach was fabricated by incorporating graphene quantum dots (GCD) and 1-butylpyridinium bromide (BPBr) in the formulation of a carbon paste electrode (GQD/BPBr/CPE). The GQD was synthesized and characterized TEM method and results confirmed them as being spherical with of 5.0 nm. The applicability of the GQD/BPBrICPE in voltammetric analysis of 5-fluorouracil was evaluated. The relations of oxidation currents and potentials of 5-fluorouracil with pH at the surface of GQD/BPBr/CPE were investigated and the results confirmed the involvement of electrons and protons in the electro-oxidation mechanism of 5-fluorouracil. In square wave voltammetry (SWAT) analyses, the GQD/BPBr/CPE showed good sensitivity for 5-fluorouracil over a wide linear range of 0.001-400 mu M and a detection limit of 0.5 nm was achieved. The GQD/BPBr/CPE was successfully applied for the determination of 5-fluorouracil in pharmaceutical samples and acceptable results were obtained.
引用
收藏
页码：230 / 238
页数：9
相关论文
共 46 条
[1]   Voltammetric oxidation and determination of atorvastatin based on the enhancement effect of cetyltrimethyl ammonium bromide at a carbon paste electrode [J].
Abbar, Jyothi C. ;
Nandibewoor, Sharanappa T. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2013, 106 :158-164
[2]   Simultaneous determination of doxorubicin and dasatinib as two breast anticancer drugs uses an amplified sensor with ionic liquid and ZnO nanoparticle [J].
Alavi-Tabari, Seyed A. R. ;
Khalilzadeh, Mohammad A. ;
Karimi-Maleh, Hassan .
JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2018, 811 :84-88
[3]   An amplified platform nanostructure sensor for the analysis of epirubicin in the presence of topotecan as two important chemotherapy drugs for breast cancer therapy [J].
Alavi-Tabari, Seyed A. R. ;
Khalilzadeh, Mohammad A. ;
Karimi-Maleh, Hassan ;
Zareyee, Daryoush .
NEW JOURNAL OF CHEMISTRY, 2018, 42 (05) :3828-3832
[4]  
[Anonymous], 2019, EURASIAN CHEM COMMUN, V1, P559
[5]  
Atar N, 2018, J ELECTROCHEM SOC, V165, pH255, DOI [10.1149/2.1311805JES, 10.1149/2.1311805jes]
[6]   Palladium nanoclusters-coated polyfuran as a novel sensor for catecholamine neurotransmitters and paracetamol [J].
Atta, Nada F. ;
El-Kady, Maher F. ;
Galal, Ahmed .
SENSORS AND ACTUATORS B-CHEMICAL, 2009, 141 (02) :566-574
[7]   Simultaneous Electrochemical Determination of Acetaminophen and Codeine Based on a MWCNT/MCM48 Nanocomposite Modified Glassy Carbon [J].
Babaei, Ali ;
Babadi, Sara Soleimani ;
Sohrabi, Masoud .
JOURNAL OF NANOSTRUCTURES, 2019, 9 (02) :190-201
[8]   A Voltammetric Sensor for Simultaneous Determination of Vitamin C and Vitamin B6 in Food Samples Using ZrO2 Nanoparticle/Ionic Liquids Carbon Paste Electrode [J].
Baghizadeh, Amin ;
Karimi-Maleh, Hassan ;
Khoshnama, Zahra ;
Hassankhani, Asadollah ;
Abbasghorbani, Maryam .
FOOD ANALYTICAL METHODS, 2015, 8 (03) :549-557
[9]   Rapid, sensitive, and reusable detection of glucose by highly monodisperse nickel nanoparticles decorated functionalized multi-walled carbon nanotubes [J].
Baskaya, Gaye ;
Yildiz, Yunus ;
Savk, Aysun ;
Okyay, Tugba Onal ;
Eris, Sinan ;
Sert, Hakan ;
Sen, Fatih .
BIOSENSORS & BIOELECTRONICS, 2017, 91 :728-733
[10]   A highly selective and sensitive voltammetric sensor with molecularly imprinted polymer based silver@gold nanoparticles/ionic liquid modified glassy carbon electrode for determination of ceftizoxime [J].
Beytur, Murat ;
Kardas, Faruk ;
Akyildirim, Onur ;
Ozkan, Abdullah ;
Bankoglu, Bahar ;
Yuksek, Haydar ;
Yola, Mehmet Lutfi ;
Atar, Necip .
JOURNAL OF MOLECULAR LIQUIDS, 2018, 251 :212-217
12345