Serum lipid levels in patients with periodontal disease: A meta-analysis and meta-regression

被引:81
作者
Nepomuceno, Rafael [1 ]
Pigossi, Suzane C. [1 ]
Finoti, Livia S. [2 ]
Orrico, Silvana R. P. [1 ]
Cirelli, Joni A. [1 ]
Barros, Silvana P. [3 ]
Offenbacher, Steven [3 ]
Scarel-Caminaga, Raquel M. [4 ]
机构
[1] Sao Paulo State Univ UNESP, Dept Diag & Surg, Sch Dent Araraquara, Araraquara, SP, Brazil
[2] Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA
[3] Univ North Carolina Chapel Hill, Sch Dent, Dept Periodontol, Chapel Hill, NC USA
[4] Sao Paulo State Univ UNESP, Dept Morphol, Sch Dent Araraquara, Araraquara, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
cholesterol; dyslipidaemia; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; periodontal disease; triglycerides; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; GENDER; DEFINITIONS; ASSOCIATION; SENSITIVITY; PROFILES; HEALTH;
D O I
10.1111/jcpe.12792
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
AimSeveral papers have considered the potential relationship between periodontitis and lipid parameters. The present systematic review, meta-analysis and meta-regression studies focused on investigating whether serum lipid parameter levels were elevated in patients with periodontal disease (PD; without altered systemic conditions) in comparison with periodontally healthy subjects. Materials and MethodsEligible studies were those with data about serum lipid parameter levels in non-smoking subjects with and without chronic periodontitis, who are generally healthy and not taking any medication for dyslipidaemia. Mean differences and 95% confidence intervals for total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol were obtained from all the selected studies. ResultsA total of 19 publications were included for meta-analysis. Participants with chronic periodontitis presented significantly higher serum levels of LDL and triglycerides (p=.003 and p<.0001, respectively). The total cholesterol was higher in the PD group, but without significant difference in comparison with healthy participants. Significantly (p=.0005) lower HDL serum levels were found in patients with chronic periodontitis than in healthy subjects. ConclusionsEven considering the limitations of this meta-analysis, it is suggested that PD is significantly associated with reduction in HDL and elevation of LDL and triglyceride concentrations. This analysis supports the rationale that periodontal disease is associated with lipid metabolic control.
引用
收藏
页码:1192 / 1207
页数:16
相关论文
共 47 条
[1]   Superoxide dismutase activity in gingiva in type-2 diabetes mellitus patients with chronic periodontitis [J].
Akalin, Ferda Alev ;
Isiksal, Eda ;
Baltacioglu, Esra ;
Renda, Nurten ;
Karabulut, Erdem .
ARCHIVES OF ORAL BIOLOGY, 2008, 53 (01) :44-52
[2]   Effects of menopause, gender and age on lipids and high-density lipoprotein cholesterol subfractions [J].
Anagnostis, Panagiotis ;
Stevenson, John C. ;
Crook, David ;
Johnston, Desmond G. ;
Godsland, Ian F. .
MATURITAS, 2015, 81 (01) :62-68
[3]   Nitric oxide production, systemic inflammation and lipid metabolism in periodontitis patients: possible gender aspect [J].
Andrukhov, Oleh ;
Haririan, Hady ;
Bertl, Kristina ;
Rausch, Wolf-Dieter ;
Bantleon, Hans-Peter ;
Moritz, Andreas ;
Rausch-Fan, Xiaohui .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2013, 40 (10) :916-923
[4]   Comparison of the clinical features of chronic and aggressive periodontitis [J].
Armitage, Gary C. ;
Cullinan, Mary P. .
PERIODONTOLOGY 2000, 2010, 53 :12-27
[5]  
Awartani Fatin, 2010, J Contemp Dent Pract, V11, P033
[6]   Correlation of Toll-Like Receptor 4, Interleukin-18, Transaminases, and Uric Acid in Patients With Chronic Periodontitis and Healthy Adults [J].
Banu, Shaheena ;
Jabir, Nasimudeen R. ;
Mohan, Rekha ;
Manjunath, Nanjappa C. ;
Kamal, Mohammad Amjad ;
Kumar, Kopparam Rajendra Vinod ;
Zaidi, Syed Kashif ;
Khan, Mohd Shahnawaz ;
Tabrez, Shams .
JOURNAL OF PERIODONTOLOGY, 2015, 86 (03) :431-439
[7]   EVALUATING PERIODONTAL STATUS OF US EMPLOYED ADULTS [J].
BROWN, LJ ;
OLIVER, RC ;
LOE, H .
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION, 1990, 121 (02) :226-232
[8]   Metabolic Syndrome and Periodontitis: Is Oxidative Stress a Common Link? [J].
Bullon, P. ;
Morillo, J. M. ;
Ramirez-Tortosa, M. C. ;
Quiles, J. L. ;
Newman, H. N. ;
Battino, M. .
JOURNAL OF DENTAL RESEARCH, 2009, 88 (06) :503-518
[9]   Diurnal and acute patterns of postprandial apolipoprotein B-48 in VLDL, IDL, and LDL from normolipidemic humans [J].
Campos, H ;
Khoo, C ;
Sacks, FA .
ATHEROSCLEROSIS, 2005, 181 (02) :345-351
[10]   Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia [J].
Cutler, CW ;
Machen, RL ;
Jotwani, R ;
Iacopino, AM .
JOURNAL OF PERIODONTOLOGY, 1999, 70 (11) :1313-1321