Genotypic and Phenotypic Trends in Antibiotic Resistant Pathogenic Escherichia coli Isolated from Humans and Farm Animals in South Korea

被引：15

作者：

Unno, Tatsuya ^{[1
]}

Han, Dukki ^{[1
]}

Jang, Jeonghwan ^{[1
]}

Widmer, Kenneth ^{[2
]}

Ko, GwangPyo ^{[3
]}

Sadowsky, Michael J. ^{[4
,5
]}

Hur, Hor-Gil ^{[1
,2
]}

机构：

[1] Gwangju Inst Sci & Technol, Dept Environm Sci & Engn, Kwangju 500712, South Korea

[2] Gwangju Inst Sci & Technol, Internat Environm Res Ctr, Kwangju 500712, South Korea

[3] Seoul Natl Univ, Dept Environm Publ Hlth, Seoul 110799, South Korea

[4] Univ Minnesota, Dept Soil Water & Climate, St Paul, MN 55108 USA

[5] Univ Minnesota, Inst Biotechnol, St Paul, MN 55108 USA

来源：

MICROBES AND ENVIRONMENTS | 2011年 / 26卷 / 03期

关键词：

antibiotic resistance; virulence genes; Escherichia coli; South Korea; IDENTIFICATION; STRAINS; INTEGRONS; ADHESINS; OUTBREAK; BACTERIA; GENES; ASSAY;

D O I：

10.1264/jsme2.ME10194

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

South Korea uses more antibiotics for animal production than any other member of the OECD. The excessive use could potentially lead to a greater incidence of antibiotic resistant microorganisms, some of which may be pathogenic. In this study, we examined potential diarrheagenic and extraintestinal pathogenic E. coli (ExPEC) isolates using virulence gene profiling (eaeA, est, elt, ipaH, stx1 and stx2 as diarrheagenic and afa/dra, iutA, kpsMT II, papA/C, and sfa/foc as extraintestinal pathogenic virulence genes). A cluster analysis of DNA fingerprint data indicated that certain genotypes of chicken E. coli isolates are likely ExPEC. Moreover, our results showed 38 of the 60 potential diarrheagenic and ExPEC isolates obtained from animals and humans were also resistant to antibiotics, mostly to tetracycline groups, penicillin groups, and folate pathway inhibitors. Our results suggest that the use of antibiotics in agriculture should be controlled due to potential impacts on human health.

引用

页码：198 / 204

页数：7

共 38 条

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