About Mayaro virus, there is currently little knowledge of its transmission and pathogenesis. It is known to inhabit different areas of the Western Hemisphere and is transmitted by the Aedes aegypti and albopictus (Diptera: Culicidae). Numerous authors have focused their research given coexistence in scenarios where the circulations of all these viruses can somehow overlap and generate mixed infections. This agent has been gaining prominence at the public health level, due to the possibility of causing high risk of outbreaks with serious clinical manifestations similar to that of Zika viruses, Chikungunya virus and Dengue, in several countries, such as Trinidad, Brazil, Mexico, Venezuela, Honduras, Salvador, Costa Rica, Panama, Peru, Argentina, Suriname, Guyana, Venezuela, Ecuador and Bolivia. Colombia is looking forward to a concomitant onset in the near future along with ZIKV and CHIKV. Taking into account the above, a thorough search was carried out of the existing literature, on Mayaro virus, its molecular structure, transmission cycle, clinical symptomatology, diagnostic methods, risk factors, control and prevention, as well as treatment, to learn a broader picture of the problem that lurks. All this, through search engines like PubMed, Science Direct, Clinical Key and Ebsco.