Next-generation precision antimicrobials: towards personalized treatment of infectious diseases

被引：97

作者：

de la Fuente-Nunez, Cesar ^{[1
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Torres, Marcelo D. T. ^{[1
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Mojica, Francisco J. M. ^{[9
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Lu, Timothy K. ^{[1
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机构：

[1] MIT, Synthet Biol Ctr, Synthet Biol Grp, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] MIT, Res Lab Elect, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[4] MIT, Dept Elect Engn & Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[5] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[6] Harvard Univ, Harvard Biophys Program, Boston, MA 02115 USA

[7] Ctr Microbiome Informat & Therapeut, Cambridge, MA 02139 USA

[8] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Sao Paulo, Brazil

[9] Univ Alicante, Dept Fisiol Genet & Microbiol, Pavil 12, E-03080 Alicante, Spain

来源：

CURRENT OPINION IN MICROBIOLOGY | 2017年 / 37卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

SEQUENCE-SPECIFIC ANTIMICROBIALS; PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS; PSEUDOMONAS-AERUGINOSA; ANTIBIOFILM PEPTIDES; BIOFILM FORMATION; MICROBIOME; INHIBITION; IDENTIFICATION; ANTIBIOTICS; TECHNOLOGY;

D O I：

10.1016/j.mib.2017.05.014

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibiotics started to be used almost 90 years ago to eradicate life-threatening infections. The urgency of the problem required rapid, broad-spectrum elimination of infectious agents. Since their initial discovery, these antimicrobials have saved millions of lives. However, they are not exempt from side effects, which include the indiscriminate disruption of the beneficial microbiota. Recent technological advances have enabled the development of antimicrobials that can selectively target a gene, a cellular process, or a microbe of choice. These strategies bring us a step closer to developing personalized therapies that exclusively remove disease-causing infectious agents. Here, we advocate the preservation of our beneficial microbes and provide an overview of promising alternatives to broad-spectrum antimicrobials. Specifically, we emphasize nucleic acid and peptide-based systems as a foundation for next-generation alternatives to antibiotics that do not challenge our microbiota and may help to mitigate the spread of resistance.

引用

页码：95 / 102

页数：8

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