Pd(TFA)2-catalyzed direct arylation of quinoxalinones with arenes

被引：61

作者：

Paul, Sanjay ^{[1
,2
]}

Khanal, Hari Datta ^{[1
]}

Clinton, Chayan Dhar ^{[1
]}

Kim, Sung Hong ^{[3
]}

Lee, Yong Rok ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 712749, South Korea

[2] Behala Coll, Dept Chem, Kolkata 700060, India

[3] Korea Basic Sci Inst, Anal Res Div, Daegu Ctr, Daegu 41566, Daegu 41566, South Korea

来源：

ORGANIC CHEMISTRY FRONTIERS | 2019年 / 6卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

ALDOSE REDUCTASE INHIBITORS; C-H FUNCTIONALIZATIONS; OXIDATIVE ARYLATION; COUPLING REACTIONS; BOND FORMATION; QUINOXALIN-2(1H)-ONES; POTENT; ACTIVATION; IODOSOBENZENE; ALKENYLATION;

D O I：

10.1039/c8qo01250d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct C-3 arylation of quinoxalin-2-ones with arenes is achieved by a Pd(TFA)(2)-catalyzed cross-dehydrogenative coupling (CDC) reaction. A wide array of functionalities, including highly sensitive allyl- and benzyl group substituted quinoxalin-2(H)-ones, are readily assembled with arenes containing electron-donating and electron-withdrawing groups in this CDC reaction. Highly regioselective products are produced in good yields with stronger electron-donating groups than toluene and densely substituted arenes as coupling partners. This protocol represents an efficient technique to access various 3-aryl-benzo[g]quinoxalinones and 2-aryl-4-methylpyrido[3,4-b]pyrazin-3(4H)-ones under mild conditions.

引用

页码：231 / 235

页数：5

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