Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)

被引：414

作者：

Kumar, Pankaj ^{[1
]}

Kuscu, Canan ^{[1
]}

Dutta, Anindya ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22901 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 08期

关键词：

WIDE IDENTIFICATION; STRESS-RESPONSE; DICER; ANGIOGENIN; MUTATION; REVEALS; PROTEIN; NSUN2; PROLIFERATION; TRANSLATION;

D O I：

10.1016/j.tibs.2016.05.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Noncoding small RNAs arise from the various un-annotated and annotated regions of the genome. When they arise from annotated genes, the noncoding small RNAs are functionally different from the parent genes. This is a brief review of one class of noncoding small RNAs, tRNA-related fragments (tRFs), which are generated from tRNA. tRFs have been suggested to have roles in cell proliferation, priming of viral reverse transcriptases, regulation of gene expression, RNA processing, modulation of the DNA damage response, tumor suppression, and neurodegeneration.

引用

页码：679 / 689

页数：11

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