Use of the equilibrium-dispersive model of nonlinear gas chromatography for the modelling of the elution band profiles in the preparative-scale gas chromatographic separation of enantiomers

The equilibrium-dispersive model of chromatography is applied to the study of enantioselective separations of methyl 2-chloropropionate in gas chromatography. The single-component and competitive bi-Langmuir isotherm equations that describe the sorption behavior of single enantiomers and racemates, respectively, are utilized by the equilibrium-dispersive model to predict the elution band profiles of single-component and binary mixture samples. The measured and the calculated band profiles are compared both for the analytical open tubular column used to acquire the isotherm data and for the 1 mX22.5 mm I.D. preparative packed column, followed by the comparison of the enantiomeric purity vs. production curves for both the measured and the simulated systems.