Effects of the ancillary ligands of polypyridyl ruthenium(II) complexes on the DNA-binding and photocleavage behaviors

被引：55

作者：

Tan, Li-Feng ^{[1
]}

Chao, Hui ^{[2
]}

Zhen, Kang-Cheng ^{[2
]}

Fei, Jun-Jie ^{[1
]}

Wang, Fang ^{[1
]}

Zhou, Yang-Fan ^{[1
]}

Ji, Liang-Nian ^{[2
]}

机构：

[1] Xiangtan Univ, Coll Chem, Xiangtan 411105, Peoples R China

[2] Sun Yat Sen Univ, Dept Chem, Guangzhou 510275, Peoples R China

来源：

POLYHEDRON | 2007年 / 26卷 / 18期

关键词：

ruthenium(II) complex; polypyridyl ligand; DNA-binding; photocleavage;

D O I：

10.1016/j.poly.2007.08.025

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The new polypyridyl ligand MIP {MIP=2-(2,3-methylenedioxyphenyl)imidazo[4,5-f]1,10-phenanthroline} and its ruthenium(II) complexes [Ru(phen)(2)(MIP)](2+) (1) (phen = 1,10-phenanthroline) and [Ru(dmp)(2)(MIP)](2+) (2) (dmp = 2,9-dimethyl-1,10-phenanthroline) were synthesized and characterized by elemental analysis, MS and H-1 NMR spectroscopy. The DNA-binding properties of the two complexes to calf-thymus DNA (CT-DNA) were investigated by different spectrophotometric methods and viscosity measurements, as well as equilibrium dialysis and circular dichroism spectroscopy. The results suggest that complex I binds to CT-DNA through intercalation, and complex 2 binds to CT-DNA via a partial intercalative mode. This difference in binding mode probably is caused by the different ancillary ligands. Also, when irradiated at 400 nm, complex 1 was found to be a more-effective DNA-cleaving agent than complex 2. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：5458 / 5468

页数：11

共 54 条

[21] Density functional MO calculation for stacked DNA base-pairs with backbones [J].

Kurita, N ;

Kobayashi, K .

COMPUTERS & CHEMISTRY, 2000, 24 (3-4) :351-357

[22] Synthesis, characterization and DNA binding studies of two mixed ligand complexes of ruthenium(II) [J].

Lawrence, D. ;

Vaidyanathan, V. G. ;

Nair, Balachandran Unni .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2006, 100 (07) :1244-1251

[23] Interaction of [Ru(dmp)2(dppz)2+ and [Ru(dmb)2(dppz)]2+ with DNA:: Effects of the ancillary ligands on the DNA-binding behaviors [J].

Liu, JG ;

Zhang, QL ;

Shi, XF ;

Ji, LN .

INORGANIC CHEMISTRY, 2001, 40 (19) :5045-+

[24] Synthesis, characterization and interaction of mixed polypyridyl ruthenium(II) complexes with calf thymus DNA [J].

Liu, JG ;

Zhang, QL ;

Ji, LN ;

Cao, YY ;

Shi, XF .

TRANSITION METAL CHEMISTRY, 2001, 26 (06) :733-738

[25] Ruthenium(II) mixed-ligand complexes containing 2-(6-methyl-3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline: Synthesis, DNA-binding and photocleavage studies [J].

Liu, Yun-Jun ;

Chao, Hui ;

Yuan, Yi-Xian ;

Yu, Hui-Juan ;

Ji, Liang-Nian .

INORGANICA CHIMICA ACTA, 2006, 359 (12) :3807-3814

[26] DNA binding and cleavage activity of [Ru(NH3)4(diimine)]Cl2 complexes [J].

Maheswari, PU ;

Palaniandavar, M .

INORGANICA CHIMICA ACTA, 2004, 357 (04) :901-912

[27] PROCEDURE FOR ISOLATION OF DEOXYRIBONUCLEIC ACID FROM MICRO-ORGANISMS [J].

MARMUR, J .

JOURNAL OF MOLECULAR BIOLOGY, 1961, 3 (02) :208-&

[28] TRIS(TETRAMETHYLPHENANTHROLINE)RUTHENIUM(II) - A CHIRAL PROBE THAT CLEAVES A-DNA CONFORMATIONS [J].

MEI, HY ;

BARTON, JK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1339-1343

[29] Kinetically inert transition metal complexes that reversibly bind to DNA [J].

Metcalfe, C ;

Thomas, JA .

CHEMICAL SOCIETY REVIEWS, 2003, 32 (04) :215-224

[30] Synthesis, spectroscopic, electrochemical and antibacterial studies of new Ru(II) 1,10-phenanthroline complexes containing aryldiazopentane-2,4-dione as co-ligand [J].

Mishra, L ;

Yadaw, AK ;

Srivastava, S ;

Patel, AB .

NEW JOURNAL OF CHEMISTRY, 2000, 24 (07) :505-510

← 1 2 3 4 5 6 →