A Reactive Oxygen Species (ROS) Activated Hydrogen Sulfide (H2S) Donor with Self-Reporting Fluorescence

被引：54
作者：
Zhang, Ning [1 ,2 ]
Hu, Ping [1 ,2 ]
Wang, Yanfang [3 ]
Tang, Qing [1 ,2 ]
Zheng, Qiang [1 ,2 ]
Wang, Zhanlong [1 ,2 ]
He, Yun [1 ,2 ]
机构：
[1] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China
[2] Chongqing Univ, Chongqing Key Lab Nat Drug Res, Chongqing 401331, Peoples R China
[3] Shihezi Univ, Med Coll, Affiliated Hosp 1, Xinjiang 832008, Peoples R China
来源：
ACS SENSORS | 2020年 / 5卷 / 02期
基金：
中国国家自然科学基金;
关键词：
self-reporting fluorescence; hydrogen sulfide donor; reactive oxygen species; ratiometric fluorescence; myocardial ischemia reperfusion injury; ENDOPLASMIC-RETICULUM STRESS; SUPEROXIDE ANION; PROBES; CARDIOPROTECTION; MOLECULE; INSIGHTS; INJURY; APOPTOSIS; PROTECTS; DELIVERY;
D O I：
10.1021/acssensors.9b01093
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydrogen sulfide (H2S) is an important cellular signaling molecule, and its physiological and pathophysiological properties have been under intensive investigation. In this study, a novel ratiometric fluorescent H2S donor (HSD-B) has been developed, which exhibited the following advantages: (i) scavenging ROS and producing H2S simultaneously; (ii) providing ratiometric fluorescence for visualization and quantification of H2S releasing; and (iii) targeting mitochondrion specifically. Moreover, it demonstrated protective effects on myocardial ischemia reperfusion injury in a cellular model. These attractive features promise this HSD-B as a fluorescent H2S donor for future research studies.
引用
收藏
页码：319 / 326
页数：15
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