Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure

被引：22
作者：
Martens, Colton R. [1 ]
Accornero, Federica [1 ]
机构：
[1] Ohio State Univ, Dorothy M Davis Heart & Lung Res Inst, Dept Physiol & Cell Biol, Columbus, OH 43210 USA
来源：
VIRUSES-BASEL | 2021年 / 13卷 / 10期
关键词：
cardiac inflammation; viral infection; myocarditis; cardiotropic viruses; heart failure; TUMOR-NECROSIS-FACTOR; COXSACKIEVIRUS B3-INDUCED MYOCARDITIS; ACUTE VIRAL MYOCARDITIS; HUMAN-HERPESVIRUS; 6; FACTOR-ALPHA; PARVOVIRUS B19; CARDIAC INJURY; BALB/C MICE; TH17; CELLS; T-CELLS;
D O I：
10.3390/v13101924
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Viruses are an underappreciated cause of heart failure. Indeed, several types of viral infections carry cardiovascular risks. Understanding shared and unique mechanisms by which each virus compromises heart function is critical to inform on therapeutic interventions. This review describes how the key viruses known to lead to cardiac dysfunction operate. Both direct host-damaging mechanisms and indirect actions on the immune systems are discussed. As viral myocarditis is a key pathologic driver of heart failure in infected individuals, this review also highlights the role of cytokine storms and inflammation in virus-induced cardiomyopathy.</p>
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页数：19
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