Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure

被引：22

作者：

Martens, Colton R. ^{[1
]}

Accornero, Federica ^{[1
]}

机构：

[1] Ohio State Univ, Dorothy M Davis Heart & Lung Res Inst, Dept Physiol & Cell Biol, Columbus, OH 43210 USA

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 10期

关键词：

cardiac inflammation; viral infection; myocarditis; cardiotropic viruses; heart failure; TUMOR-NECROSIS-FACTOR; COXSACKIEVIRUS B3-INDUCED MYOCARDITIS; ACUTE VIRAL MYOCARDITIS; HUMAN-HERPESVIRUS; 6; FACTOR-ALPHA; PARVOVIRUS B19; CARDIAC INJURY; BALB/C MICE; TH17; CELLS; T-CELLS;

D O I：

10.3390/v13101924

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Viruses are an underappreciated cause of heart failure. Indeed, several types of viral infections carry cardiovascular risks. Understanding shared and unique mechanisms by which each virus compromises heart function is critical to inform on therapeutic interventions. This review describes how the key viruses known to lead to cardiac dysfunction operate. Both direct host-damaging mechanisms and indirect actions on the immune systems are discussed. As viral myocarditis is a key pathologic driver of heart failure in infected individuals, this review also highlights the role of cytokine storms and inflammation in virus-induced cardiomyopathy.</p>

引用

页数：19

共 149 条

[1] COVID-19 and the Heart [J].

Akhmerov, Akbarshakh ;

Marban, Eduardo .

CIRCULATION RESEARCH, 2020, 126 (10) :1443-1455

[2] Interleukin-37 Ameliorates Coxsackievirus B3-induced Viral Myocarditis by Modulating the Th17/Regulatory T cell Immune Response [J].

An, Bang ;

Liu, Xuefei ;

Li, Ge ;

Yuan, Haitao .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2017, 69 (05) :305-313

[3] Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State [J].

Arentz, Matt ;

Yim, Eric ;

Klaff, Lindy ;

Lokhandwala, Sharukh ;

Riedo, Francis X. ;

Chong, Maria ;

Lee, Melissa .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (16) :1612-1614

[4] Cardiac involvement in the acquired immunodeficiency syndrome: A multicenter clinical-pathological study [J].

Barbaro, G ;

Di Lorenzo, G ;

Grisorio, B ;

Barbarini, G .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (12) :1071-1077

[5] Special Article - Acute myocardial injury in patients hospitalized with COVID-19 infection: A review [J].

Bavishi, Chirag ;

Bonow, Robert O. ;

Trivedi, Vrinda ;

Abbott, J. Dawn ;

Messerli, Franz H. ;

Bhatt, Deepak L. .

PROGRESS IN CARDIOVASCULAR DISEASES, 2020, 63 (05) :682-689

[6] Glutathione peroxidase protects mice from viral-induced myocarditis [J].

Beck, MA ;

Esworthy, RS ;

Ho, YS ;

Chu, FF .

FASEB JOURNAL, 1998, 12 (12) :1143-1149

[7] Increased virulence of coxsackievirus B3 in mice due to vitamin E or selenium deficiency [J].

Beck, MA .

JOURNAL OF NUTRITION, 1997, 127 :S966-S970

[8] Pathophysiologically relevant concentrations of tumor necrosis factor-α promote progressive left ventricular dysfunction and remodeling in rats [J].

Bozkurt, B ;

Kribbs, SB ;

Clubb, FJ ;

Michael, LH ;

Didenko, VV ;

Hornsby, PJ ;

Seta, Y ;

Oral, H ;

Spinale, FG ;

Mann, DL .

CIRCULATION, 1998, 97 (14) :1382-1391

[9] Possible Role of Human Herpesvirus 6 as a Trigger of Autoimmune Disease [J].

Broccolo, Francesco ;

Fusetti, Lisa ;

Ceccherini-Nelli, Luca .

SCIENTIFIC WORLD JOURNAL, 2013,

[10] Fatal parvovirus B19-associated myocarditis clinically mimicking ischemic heart disease:: An endothelial cell-mediated disease [J].

Bültmann, BD ;

Klingel, K ;

Sotlar, K ;

Bock, CT ;

Baba, HA ;

Sauter, M ;

Kandolf, R .

HUMAN PATHOLOGY, 2003, 34 (01) :92-95

← 1 2 3 4 5 6 7 8 9 10 →