The utility of the 13C-methacetin breath test in predicting the long-term survival of patients with decompensated cirrhosis

被引:4
|
作者
Moran, Segundo [1 ]
Mina, Aline [1 ]
Duque, Ximena [1 ]
Ortiz-Olvera, Nayeli [2 ]
Rodriguez-Leal, Gustavo [1 ]
Alfredo Sierra-Ramirez, Jose [3 ]
Medina-Santillan, Roberto [3 ]
Mera, Robertino M. [4 ]
Uribe, Misael [5 ]
机构
[1] CMN Siglo XXI, Lab Gastrohepatol Res, Mexican Inst Social Secur, Mexico City, DF, Mexico
[2] CMN Siglo XXI, Dept Gastroenterol, Mexican Inst Social Secur, Mexico City, DF, Mexico
[3] Inst Politecn Nacl, Super Sch Med, Mexico City, DF, Mexico
[4] Vanderbilt Univ, Div Gastroenterol Hepatol & Nutr, 221 Kirkland Hall, Nashville, TN 37235 USA
[5] Med Sur Clin & Fdn, Mexico City, DF, Mexico
关键词
C-13-methacetin breath test; cirrhosis; Child-Pugh score; liver failure; CHRONIC HEPATITIS-C; LIVER-FUNCTION ASSESSMENT; PROGNOSTIC VALUE; DISEASE; INFECTION; C-13-PHENYLALANINE; DISCRIMINATION; INDICATORS; MORTALITY; CAPACITY;
D O I
10.1088/1752-7163/aa7b99
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Aim: The C-13-methacetin breath test (C-13-MeBT) is a noninvasive tool that allows evaluation of the functional activity of the liver and the prediction of liver cirrhosis. Nevertheless, there is no information on its potential utility to predict long-termsurvival in patients with liver disease. Methods: Patients with cirrhosis were selected. All patients underwent a complete clinical assessment, standard biochemical tests, and C-13-MeBT at the beginning of the study. Death was recorded during the three years of follow-up. Survival curves were calculated by the Kaplan-Meier method, and Cox proportional risk models were used to identify predictive factors. The ability to classify the overall risk was assessed by the C statistic. Results: One hundred and twenty-three patients were included. Asignificant inverse correlation was found between delta over baseline at the 15 min point (DOB15) after ingestion of C-13-methacetin and the Child-Pugh score (r = - 0.411, p < 0.001). Inmultivariate analysis, DOB15 <= 4.5 parts per thousand was associated with mortality, [HR = 2.58 95% CI (1.17-5.69)]. In conclusion, our results confirm the utility of C-13-MeBT as a simple, noninvasive tool to quantitatively assess the liver's functional reserve and as a potential predictor of long-termsurvival in patients with decompensated cirrhosis.
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页数:7
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