The Role of TGF-β Signaling Pathways in Cancer and Its Potential as a Therapeutic Target

被引：38

作者：

Yang, Yun ^{[1
]}

Ye, Wen-Long ^{[1
]}

Zhang, Ruo-Nan ^{[1
,2
]}

He, Xiao-Shun ^{[2
]}

Wang, Jing-Ru ^{[2
]}

Liu, Yu-Xuan ^{[1
]}

Wang, Yi ^{[1
]}

Yang, Xue-Mei ^{[1
,2
]}

Zhang, Yu-Juan ^{[1
]}

Gan, Wen-Juan ^{[3
]}

机构：

[1] Soochow Univ, Med Coll, Dept Pathol, Suzhou 215123, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Pathol, Suzhou 215123, Peoples R China

[3] Soochow Univ, Dushu Lake Hosp, Dept Pathol, Suzhou 215123, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2021年 / 2021卷

基金：

中国国家自然科学基金;

关键词：

GROWTH-FACTOR-BETA; FYVE DOMAIN PROTEIN; SQUAMOUS-CELL CARCINOMA; RECEPTOR-I; TRANSFORMING GROWTH-FACTOR-BETA-1; MYOFIBROBLAST DIFFERENTIATION; TRANSCRIPTIONAL REGULATION; MULTIPLE FUNCTIONS; ACTIVATION; INHIBITOR;

D O I：

10.1155/2021/6675208

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The transforming growth factor-beta (TGF-beta) signaling pathway mediates various biological functions, and its dysregulation is closely related to the occurrence of malignant tumors. However, the role of TGF-beta signaling in tumorigenesis and development is complex and contradictory. On the one hand, TGF-beta signaling can exert antitumor effects by inhibiting proliferation or inducing apoptosis of cancer cells. On the other hand, TGF-beta signaling may mediate oncogene effects by promoting metastasis, angiogenesis, and immune escape. This review summarizes the recent findings on molecular mechanisms of TGF-beta signaling. Specifically, this review evaluates TGF-beta ' s therapeutic potential as a target by the following perspectives: ligands, receptors, and downstream signaling. We hope this review can trigger new ideas to improve the current clinical strategies to treat tumors related to the TGF-beta signaling pathway.

引用

页数：16

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