The Role of TGF-β Signaling Pathways in Cancer and Its Potential as a Therapeutic Target

被引：39
作者：
Yang, Yun [1 ]
Ye, Wen-Long [1 ]
Zhang, Ruo-Nan [1 ,2 ]
He, Xiao-Shun [2 ]
Wang, Jing-Ru [2 ]
Liu, Yu-Xuan [1 ]
Wang, Yi [1 ]
Yang, Xue-Mei [1 ,2 ]
Zhang, Yu-Juan [1 ]
Gan, Wen-Juan [3 ]
机构：
[1] Soochow Univ, Med Coll, Dept Pathol, Suzhou 215123, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Dept Pathol, Suzhou 215123, Peoples R China
[3] Soochow Univ, Dushu Lake Hosp, Dept Pathol, Suzhou 215123, Peoples R China
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2021年 / 2021卷
基金：
中国国家自然科学基金;
关键词：
GROWTH-FACTOR-BETA; FYVE DOMAIN PROTEIN; SQUAMOUS-CELL CARCINOMA; RECEPTOR-I; TRANSFORMING GROWTH-FACTOR-BETA-1; MYOFIBROBLAST DIFFERENTIATION; TRANSCRIPTIONAL REGULATION; MULTIPLE FUNCTIONS; ACTIVATION; INHIBITOR;
D O I：
10.1155/2021/6675208
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The transforming growth factor-beta (TGF-beta) signaling pathway mediates various biological functions, and its dysregulation is closely related to the occurrence of malignant tumors. However, the role of TGF-beta signaling in tumorigenesis and development is complex and contradictory. On the one hand, TGF-beta signaling can exert antitumor effects by inhibiting proliferation or inducing apoptosis of cancer cells. On the other hand, TGF-beta signaling may mediate oncogene effects by promoting metastasis, angiogenesis, and immune escape. This review summarizes the recent findings on molecular mechanisms of TGF-beta signaling. Specifically, this review evaluates TGF-beta ' s therapeutic potential as a target by the following perspectives: ligands, receptors, and downstream signaling. We hope this review can trigger new ideas to improve the current clinical strategies to treat tumors related to the TGF-beta signaling pathway.
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收藏
页数：16
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