Turning the inside out: the microbiology of atopic dermatitis

被引:28
作者
Brussow, Harald [1 ]
机构
[1] Nestle Res Ctr, Nutr & Hlth, Host Microbe Interact, Lausanne, Switzerland
关键词
STAPHYLOCOCCUS-AUREUS COLONIZATION; BACTERIAL SKIN FLORA; 1ST; 6; MONTHS; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; GUT MICROBIOTA; DOUBLE-BLIND; PROBIOTIC SUPPLEMENTATION; ANTIMICROBIAL PEPTIDES; ALLERGY DEVELOPMENT;
D O I
10.1111/1462-2920.13050
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Allergy is on the rise worldwide. The hygiene hypothesis of atopic diseases linked microbes with atopic dermatitis (AD) both as drivers and modulators of skin pathology. The earlier literature favoured an inside-outside model of AD where an immunological abnormality compounded by a gut microbiota dysbiosis is the primary event. Probiotic intervention trials with lactobacilli and bifidobacteria as well as the application of bifidogenic oligosaccharide prebiotics showed indeed promising clinical results, but no consistent gut microbiota dysbiosis could be linked with AD. An alternative hypothesis known as outside-inside model of AD considers a genetic skin barrier effect compounded by a skin microbiota dysbiosis as primary pathogenic event. Cultivation microbiology has demonstrated strong skin colonization with superantigen-encoding Staphylococcus aureus in AD patients; microbiota and molecular microbiome analyses demonstrated that S.aureus abundance fluctuates and parallels clinical symptoms. In a mouse model, -toxin of S.aureus induced mast cell degranulation, leading to AD-like symptoms. Mutant mice developing AD symptoms showed increased skin colonization with S.aureus; antibiotic treatment alleviated the symptoms. Clinical trials showed that various treatments reducing S.aureus skin load also reduced AD symptoms, suggesting S.aureus as a potential critical driver of AD and a target for antimicrobial interventions other than antibiotics.
引用
收藏
页码:2089 / 2102
页数:14
相关论文
共 91 条
  • [1] Probiotics in prevention of IgE-associated eczema:: A double-blind, randomized, placebo-controlled trial
    Abrahamsson, Thomas R.
    Jakobsson, Ted
    Bottcher, Malin Fageras
    Fredrikson, Mats
    Jenmalm, Maria C.
    Bjorksten, Bengt
    Oldaeus, Goran
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (05) : 1174 - 1180
  • [2] Low diversity of the gut microbiota in infants with atopic eczema
    Abrahamsson, Thomas R.
    Jakobsson, Hedvig E.
    Andersson, Anders F.
    Bjorksten, Bengt
    Engstrand, Lars
    Jenmalm, Maria C.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (02) : 434 - U244
  • [3] Gut microbiota and development of atopic eczema in 3 European birth cohorts
    Adlerberth, Ingegerd
    Strachan, David P.
    Matricardi, Paolo M.
    Ahrne, Siv
    Orfei, Lia
    Aberg, Nils
    Perkin, Michael R.
    Tripodi, Salvatore
    Hesselmar, Bill
    Saalman, Robert
    Coates, Anthony R.
    Bonanno, Carmen L.
    Panetta, Valentina
    Wold, Agnes E.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (02) : 343 - 350
  • [4] MICROBIAL-FLORA OF ATOPIC-DERMATITIS
    ALY, R
    MAIBACH, HI
    SHINEFIELD, HR
    [J]. ARCHIVES OF DERMATOLOGY, 1977, 113 (06) : 780 - 782
  • [5] Children with atopic dermatitis who carry toxin-positive Staphylococcus aureus strains have an expansion of blood CD5- B lymphocytes without an increase in disease severity
    Arkwright, PD
    Cookson, BD
    Haeney, MR
    Sanyal, D
    Potter, MR
    David, TJ
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2001, 125 (02) : 184 - 189
  • [6] Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life
    Arslanoglu, Sertac
    Moro, Guido E.
    Schmitt, Joachim
    Tandoi, Laura
    Rizzardi, Silvia
    Boehm, Gunther
    [J]. JOURNAL OF NUTRITION, 2008, 138 (06) : 1091 - 1095
  • [7] Mechanisms of disease: The effect of infections on susceptibility to autoimmune and allergic diseases
    Bach, JF
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) : 911 - 920
  • [8] BAKER PJ, 1992, ADV EXP MED BIOL, V319, P31
  • [9] Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated Cochrane review
    Bath-Hextall, F. J.
    Birnie, A. J.
    Ravenscroft, J. C.
    Williams, H. C.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2010, 163 (01) : 12 - 26
  • [10] Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms
    Baurecht, Hansjoerg
    Hotze, Melanie
    Brand, Stephan
    Buening, Carsten
    Cormican, Paul
    Corvin, Aiden
    Ellinghaus, David
    Ellinghaus, Eva
    Esparza-Gordillo, Jorge
    Foelster-Holst, Regina
    Franke, Andre
    Gieger, Christian
    Hubner, Norbert
    Illig, Thomas
    Irvine, Alan D.
    Kabesch, Michael
    Lee, Young A. E.
    Lieb, Wolfgang
    Marenholz, Ingo
    McLean, W. H. Irwin
    Morris, Derek W.
    Mrowietz, Ulrich
    Nair, Rajan
    Noethen, Markus M.
    Novak, Natalija
    O'Regan, Grainne M.
    Schreiber, Stefan
    Smith, Catherine
    Strauch, Konstantin
    Stuart, Philip E.
    Trembath, Richard
    Tsoi, Lam C.
    Weichenthal, Michael
    Barker, Jonathan
    Elder, James T.
    Weidinger, Stephan
    Cordell, Heather J.
    Brown, Sara J.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2015, 96 (01) : 104 - 120