Systemic lupus erythematosus with refractory hemolytic anemia effectively treated with cyclosporin A: a case report

被引:6
作者
Wang, SW [1 ]
Cheng, TT [1 ]
机构
[1] Chang Gung Mem Hosp, Dept Internal Med, Sect Rheumatol Allergy & Immunol, Kaohsiung, Taiwan
关键词
cyclosporin A; hemolytic anemia; lupus;
D O I
10.1191/0961203305lu2090cr
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 51 year old woman with systemic lupus erythematosus (SLE) serially developed thrombocytopenia, arthritis, lupus nephritis, pleuritis, mesenteric vasculitis and refractory hemolytic anemia during the past 19 years prior to presentation. The woman had been managed with high doses of prednisolone, splenectomy, methylprednisolone pulse therapy and cytotoxic drugs, including oral cyclophosphamide, azathioprine, mexotrexate and monthly parenteral cyclophosphamide for hemolytic anemia. After two months of therapeutic trial with Cyclosporin A (CsA) (3 mg/kg), the follow-up hemoglobin (Hb) level was increased to 12.0 gm% and the dose of prednislone was reduced to 5 mg every other day without occurring rebound during the subsequent three months. There were no obvious side effects from the medication.
引用
收藏
页码:483 / 485
页数:3
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