Anesthetics Promoting in vitro AβPP Metabolism and Amyloid-β Toxicity

被引：2

作者：

Eckel, Barbara ^{[1
]}

Blobner, Manfred ^{[1
]}

Rammes, Gerhard ^{[1
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Anasthesiol Klin, D-81675 Munich, Germany

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 22卷

关键词：

Alzheimer's disease; amyloid; amyloid-beta protein precursor; anesthetics; in vitro; CLINICALLY RELEVANT CONCENTRATIONS; ISOFLURANE INDUCES APOPTOSIS; LONG-TERM POTENTIATION; ALZHEIMERS-DISEASE; PROTEIN-LEVELS; PEPTIDE OLIGOMERIZATION; BRAIN; AGGREGATION; HALOTHANE; CALCIUM;

D O I：

10.3233/JAD-2010-100984

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

At present, more than 35 million people worldwide have Alzheimer's disease (AD). With increasing incidence and a growing number of aged patients undergoing surgery, the relevance of a possible interaction between anesthetics and AD is growing as well. Below, we review in vitro studies investigating the effects of anesthetics on the metabolism of amyloid precursor protein and its metabolite amyloid-beta.

引用

页码：S21 / S26

页数：6

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