Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

被引:52
作者
Chen, Xuechai [1 ]
Wang, Jianan [1 ]
Tahir, Muhammad [1 ]
Zhang, Fangfang [1 ]
Ran, Yuanyuan [2 ]
Liu, Zongjian [2 ]
Wang, Juan [1 ]
机构
[1] Beijing Univ Technol, Ctr Excellence Environm Safety & Biol Effects, Beijing Int Sci & Technol Cooperat Base Antiviral, Fac Environm & Life, 100 Ping Yuan, Beijing 100124, Peoples R China
[2] Capital Med Univ, Beijing Rehabil Hosp, Dept Rehabil, Beijing 100144, Peoples R China
基金
中国国家自然科学基金;
关键词
m6A; RNA methylation; Autophagy; Obesity; Azoospermatism; Ischemic heart disease; Cancer; MESSENGER-RNA; REGULATES ADIPOGENESIS; LYSOSOMAL DYSFUNCTION; BIOLOGICAL FUNCTIONS; M(6)A METHYLATION; CELL BIOLOGY; NUCLEAR-RNA; N-6-METHYLADENOSINE; EXPRESSION; OBESITY;
D O I
10.1186/s13578-021-00661-x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging. N6-methyladenosine (m6A) is the most common RNA modification in eukaryotic cells, and the fate of m6A modified transcripts is controlled by m6A RNA binding proteins. m6A modification influences mRNA alternative splicing, stability, translation, and subcellular localization. Intriguingly, recent studies show that m6A RNA methylation could alter the expression of essential autophagy-related (ATG) genes and influence the autophagy function. Thus, both m6A modification and autophagy could play a crucial role in the onset and progression of various human diseases. In this review, we summarize the latest studies describing the impact of m6A modification in autophagy regulation and discuss the role of m6A modification-autophagy axis in different human diseases, including obesity, heart disease, azoospermatism or oligospermatism, intervertebral disc degeneration, and cancer. The comprehensive understanding of the m6A modification and autophagy interplay may help in interpreting their impact on human diseases and may aid in devising future therapeutic strategies.
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页数:15
相关论文
共 115 条
[1]   Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy [J].
Aas, Aleksander ;
Isakson, Pauline ;
Bindesboll, Christian ;
Alemu, Endalkachew A. ;
Klungland, Arne ;
Simonsen, Anne .
PLOS ONE, 2017, 12 (03)
[2]   Autophagy in kidney disease: Advances and therapeutic potential [J].
Bhatia, Divya ;
Choi, Mary E. .
AUTOPHAGY IN HEALTH AND DISEASE, 2020, 172 :107-133
[3]   Epigenetic modifications of autophagy in cancer and cancer therapeutics [J].
Bhol, Chandra S. ;
Panigrahi, Debasna P. ;
Praharaj, Prakash P. ;
Mahapatra, Kewal K. ;
Patra, Srimanta ;
Mishra, Soumya R. ;
Behera, Bishnu P. ;
Bhutia, Sujit K. .
SEMINARS IN CANCER BIOLOGY, 2020, 66 :22-33
[4]  
BOKAR JA, 1994, J BIOL CHEM, V269, P17697
[5]   Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration [J].
Chen, Jian ;
Xie, Jun-Jun ;
Jin, Meng-Yun ;
Gu, Yun-Tao ;
Wu, Cong-Cong ;
Guo, Wei-Jun ;
Yan, Ying-Zhao ;
Zhang, Zeng-Jie ;
Wang, Jian-Le ;
Zhang, Xiao-Lei ;
Lin, Yan ;
Sun, Jia-Li ;
Zhu, Guang-Hui ;
Wang, Xiang-Yang ;
Wu, Yao-Sen .
CELL DEATH & DISEASE, 2018, 9
[6]  
Chen JX, 2019, AM J CANCER RES, V9, P752
[7]   The role of m6A RNA methylation in human cancer [J].
Chen, Xiao-Yu ;
Zhang, Jing ;
Zhu, Jin-Shui .
MOLECULAR CANCER, 2019, 18 (1)
[8]   RNA methylation and diseases: experimental results, databases, Web servers and computational models [J].
Chen, Xing ;
Sun, Ya-Zhou ;
Liu, Hui ;
Zhang, Lin ;
Li, Jian-Qiang ;
Meng, Jia .
BRIEFINGS IN BIOINFORMATICS, 2019, 20 (03) :896-917
[9]   Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death [J].
Chen, Xuechai ;
Yu, Chunyu ;
Guo, Minjun ;
Zheng, Xiaotong ;
Ali, Sakhawat ;
Huang, Hua ;
Zhang, Lihua ;
Wang, Shensen ;
Huang, Yinghui ;
Qie, Shuyan ;
Wang, Juan .
ACS CHEMICAL NEUROSCIENCE, 2019, 10 (05) :2355-2363
[10]   Evaluation of young chickens challenged with aerosolized Salmonella Pullorum [J].
Cheng, Yiluo ;
Zhang, Sihua ;
Lu, Qin ;
Zhang, Wenting ;
Wen, Guoyuan ;
Luo, Qingping ;
Shao, Huabin ;
Zhang, Tengfei .
AVIAN PATHOLOGY, 2020, 49 (05) :507-514