Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects

被引：156

作者：

Mansour, Heidi M. ^{[1
]}

Sohn, MinJi ^{[1
]}

Al-Ghananeem, Abeer ^{[1
]}

DeLuca, Patrick P. ^{[1
]}

机构：

[1] Univ Kentucky, Coll Pharm, Div Pharmaceut Sci, Lexington, KY 40536 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2010年 / 11卷 / 09期

关键词：

polymers; copolymers; biomaterials; biodegradable; microparticle; nanoparticle; pharmaceutical dosage forms; particle engineering design; manufacture; IN-VITRO RELEASE; LACTIDE-CO-GLYCOLIDE; BLOCK-COPOLYMERS; PARTICLE-SIZE; OSMOTIC PUMP; DICLOFENAC SODIUM; VIVO EVALUATION; GROWTH-HORMONE; GENE DELIVERY; POLY(D; L-LACTIDE-CO-GLYCOLIDE); MICROSPHERES;

D O I：

10.3390/ijms11093298

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immediate release delivery. These advantages include reduced dosing frequency, better therapeutic control, fewer side effects, and, consequently, these dosage forms are well accepted by patients. Advances in polymer material science, particle engineering design, manufacture, and nanotechnology have led the way to the introduction of several marketed controlled release products and several more are in pre-clinical and clinical development.

引用

页码：3298 / 3322

页数：25

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