Synthesis of α-Ketone-isoquinoline Derivatives via Tandem Ruthenium(II)-Catalyzed C-H Activation and Annulation

被引：34

作者：

Wu, Xiao-Lin ^{[1
]}

Dong, Lin ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Sichuan, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 22期

关键词：

PALLADIUM-CATALYZED IMINOANNULATION; AROMATIC KETIMINES; CARDIOTONIC AGENTS; ALKYNES; PYRIDINES; 4-AROYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES; BENZYLAMINES; CYCLIZATION; QUINOLINES; ACYLATION;

D O I：

10.1021/acs.orglett.8b02759

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new ruthenium(II)-catalyzed tandem C-H activation/cyclization/hydrolysis cascade process of 2H-imidazoles and alkynes for facile and regioselective access to alpha-ketone-isoquinolines has been successfully developed. 2H-Imidazole as the novel traceless directing group has been well applied in this paper. The protocol features mild reaction conditions and easily accessible starting materials, and alpha-ketone-isoquinolines could be applied to further construct more complex heterocyclic compounds.

引用

收藏

页码：6990 / 6993

页数：4

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