The age-calibrated measured glomerular filtration rate improves living kidney donation selection process

被引：30

作者：

Gaillard, Francois ^{[1
,2
]}

Courbebaisse, Marie ^{[2
,3
,4
]}

Kamar, Nassim ^{[5
,6
,7
]}

Rostaing, Lionel ^{[8
]}

Del Bello, Arnaud ^{[5
,6
]}

Girerd, Sophie ^{[9
]}

Kessler, Michele ^{[9
]}

Flamant, Martin ^{[10
,11
]}

Vidal-Petiot, Emmanuelle ^{[10
,11
]}

Peraldi, Marie-Noelle ^{[11
,12
]}

Couzi, Lionel ^{[13
,14
]}

Merville, Pierre ^{[13
,14
]}

Malvezzi, Paolo ^{[8
]}

Janbon, Benedicte ^{[8
]}

Moulin, Bruno ^{[15
]}

Caillard, Sophie ^{[15
]}

Gatault, Philippe ^{[16
,17
]}

Buchler, Matthias ^{[16
,17
]}

Maillard, Nicolas ^{[18
]}

Dubourg, Laurence ^{[19
,20
]}

Roquet, Olga ^{[19
]}

Garrouste, Cyril ^{[21
]}

Legendre, Christophe ^{[1
,2
]}

Delanaye, Pierre ^{[22
]}

Mariat, Christophe ^{[18
]}

机构：

[1] Hop Necker Enfants Malad, AP HP, Renal Transplantat Dept, Paris, France

[2] Paris Descartes Univ, Sorbonne Paris Cite, Paris, France

[3] Georges Pompidou European Hosp, AP HP, Physiol Dept, Paris, France

[4] INSERM, Unit 1151, Paris, France

[5] Ctr Hosp Univ CHU Rangueil, Dept Nephrol, Toulouse, France

[6] Ctr Hosp Univ CHU Rangueil, Dept Organ Transplantat, Toulouse, France

[7] Univ Paul Sabatier, Inst Federatif Rech BioMed Toulouse, INSERM, U1043, Toulouse, France

[8] CHU Grenoble, Nephrol & Transplantat Dept, Grenoble, France

[9] CHU Nancy, Dept Nephrol, Nancy, France

[10] Hop Xavier Bichat, AP HP, Physiol Dept, Paris, France

[11] Paris Diderot Univ, Sorbonne Paris Cite, Paris, France

[12] St Louis Hosp, AP HP, Nephrol & Transplantat Dept, Paris, France

[13] Bordeaux Univ Hosp, Dept Nephrol Transplantat Dialysis & Apheresis, Bordeaux, France

[14] Bordeaux Univ, Immuno ConcEpT, CNRS, UMR 5164, Bordeaux, France

[15] Hop Univ Strasbourg, Nouvel Hop Civil, Dept Nephrol & Transplantat, Strasbourg, France

[16] Ctr Hosp Reg Univ Tours, Nephrol Dialysis & Renal Transplantat Dept, Tours, France

[17] Francois Rabelais Univ, Cellules Dendrit Immunomodulat & Greffes EA4245, Tours, France

[18] Jean Monnet Univ, Communaute Univ & Etab Univ Lyon, CHU St Etienne, Nephrol Dialysis & Renal Transplantat Dept,Hop No, Lyon, France

[19] Hosp Civils Lyon, Explorat Fonct Renale & Metab, Lyon, France

[20] Univ Claude Bernard, CNRS, UMR 5305, Biol Tissulaire & Ingn Therapeut, Lyon, France

[21] CHU Clermont Ferrand, Dept Nephrol, Clermont Ferrand, France

[22] Univ Liege CHU ULg, Dept Nephrol, Dialysis, Transplantat, Liege, Belgium

来源：

KIDNEY INTERNATIONAL | 2018年 / 94卷 / 03期

关键词：

age; living kidney donors; measured GFR; threshold; RENAL-FUNCTION; REFERENCE VALUES; DONORS; CLEARANCE; DISEASE; RISK;

D O I：

10.1016/j.kint.2018.05.016

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Recommendations on the glomerular filtration rate (GFR) threshold compatible with living kidney donation are not agreed upon. The recent KDIGO guidelines suggested a reset of the conventional cutoff value of 80 to 90 mL/min/1.73 m(2). While GFR physiologically declines with age, it is unclear whether and how age should be taken into account for selecting acceptable pre-donation GFR. In this multicenter retrospective study encompassing 2007 kidney donors in France, we evaluated the impact of age using two threshold measured GFR (mGFR) s (80 and 90 mL/min/1.73 m(2)). Three groups of donors were defined according to baseline mGFR: below 80, 80-89.9 and 90 mL/min/1.73 m(2) or more. Thirty-two percent of donors were selected despite an mGFR below 90 mL/min/1.73 m(2). Donors with the lowest mGFR were significantly older (60 +/- 9 vs. 47 +/- 11 years) and this applied to both male and female donors. The lifetime-standardized renal reserve, defined as the pre-donation mGFR value divided by the expected number of remaining years of life, was similar irrespective of baseline mGFR groups. Similar results were obtained when eGFR was used instead of mGFR. Finally, in a subgroup of 132 donors with repeated mGFR five years after donation, the magnitude of mGFR decrease was similar in all groups (-34.3%, -33.9%, and -34.9% respectively). Thus, the decision to accept individuals with mGFR lower than 90 mL/min/1.73 m(2) for kidney donation is highly dependent on the age of the candidate. Hence, threshold values lower than 90 mL/min/1.73 m(2) are reasonable for older donors. Age-calibrated mGFR may improve efficiency of the selection process.

引用

页码：616 / 624

页数：9

共 31 条

[1] European Renal Best Practice Guideline on kidney donor and recipient evaluation and perioperative care [J].