THE ROLE OF CD34-POSITIVE CELLS IN THE ANGIOGENESIS OF MALIGNANT TISSUES

被引：0

作者：

Reva, Ivan ^{[1
,2
]}

Stegniy, Kirill ^{[1
]}

Dvoinikova, Ekaterina ^{[1
]}

Mozhilevskaya, Ekaterina

Fleischman, Marina

Ichenko, Stanislav ^{[1
]}

Tolmachev, Valeriy ^{[1
]}

Sementsov, Igor

Slabenko, Ellada ^{[1
]}

Zvyagintsev, Dmitriy ^{[1
]}

Gorbarenko, Rodion ^{[1
]}

Zolotov, Aleksandr ^{[1
]}

Obydennikova, Tamara ^{[3
]}

Reva, Galina ^{[1
,2
]}

机构：

[1] Far Eastern Fed Univ, Vladivostok, Russia

[2] Int Med Educ & Res Ctr, Niigata, Japan

[3] Pacific State Med Univ, Vladivostok, Russia

来源：

ARCHIV EUROMEDICA | 2022年 / 12卷 / 01期

关键词：

angiogenesis; CD34; Vascular endothelial growth factor (VEGF); malignancy; vessels; targeted treatment; inhibition of angiogenesis; VEGF; EXPRESSION;

D O I：

10.35630/2199-885X/2022/12/1.2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Development of methods for targeted treatment aimed at inhibiting angiogenesis in malignant tissues is of great importance for modern oncology. The features of expression of CD34-positive cells at the border of the tumor and malignant tissue were studied. High expression of CD34-positive cells in small and large vessels during malignancy and is in correlation with the size of the tumor and the age of the disease. A promising target for targeted treatment is VEGF, as the main regulator of angiogenesis during tissue malignancy.

引用

页码：8 / 10

页数：3

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