The neuronal growth and regeneration associated Cntn1 (F3/F11/Contactin) gene is duplicated in fish: expression during development and retinal axon regeneration

被引：43

作者：

Haenisch, C

Diekmann, H

Klinger, M

Gennarini, G

Kuwada, JY

Stuermer, CAO

机构：

[1] Univ Konstanz, Dept Biol, D-78457 Constance, Germany

[2] Univ Bari, Dept Pharmacol & Human Physiol, Sch Med, I-70124 Bari, Italy

[3] Univ Michigan, Ann Arbor, MI 48109 USA

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2005年 / 28卷 / 02期

关键词：

D O I：

10.1016/j.mcn.2004.04.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Cntn1 (Contactin/F3/F11) cell adhesion molecule is involved in axon growth and guidance, fasciculation, synapse formation, and myelination in birds and mammals. We identified Cntn1 genes in goldfish, zebrafish, and fugu, and provide evidence for a fish-specific duplication leading to Cntn1a and Cntn1b. Our analyses suggest a subfunctionalization for the Cntn1 paralogs in zebrafish compared to other vertebrates which have a single Cntn1 gene. Similar to Cntn1a, Cntn1b transcripts are found in subsets of sensory and motor neurons. However, Cntn1b is detected later and more restricted than Cntn1a. This spatio-temporal expression pattern of the two zebrafish Cntn1 paralogs suggests functions related to those of mammalian Cntn1. In adult goldfish, Cntn1b is expressed in oligodendrocytes and is upregulated in retinal ganglion cells after optic nerve transection, which is consistent with an additional role during regeneration. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：361 / 374

页数：14

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