Development and validation of UV-spectrophotometric method for the estimation of hydroxychloroquine sulphate

被引：0

作者：

Singh, Amit ^{[1
]}

Roopkishora ^{[1
]}

Sharma, Pradeep Kumar ^{[1
]}

Gupta, Ramji ^{[1
]}

Mondal, Nita ^{[1
]}

Kumar, Sokindra ^{[1
]}

Kumar, Mukesh ^{[2
]}

机构：

[1] RV Northland Inst, Gb Nagar 203207, Greater Noida, India

[2] KPS Clin Serv Pvt Ltd, Gb Nagar Greater Noida 201306, UP, India

来源：

INDIAN JOURNAL OF CHEMICAL TECHNOLOGY | 2016年 / 23卷 / 03期

关键词：

Hydroxychloroquine sulphate (HCQ); UV-Spectrophotometric estimation; Validation; ICH-; guidelines;

D O I：

暂无

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A simple, sensitive and accurate UV-spectrophotometric method has been developed for the determination of a hydroxychloroquine sulphate (HCQ) in raw material and pharmaceutical formulations. The parameters such as linearity, range, accuracy and stability have been determined according to International Conference on Harmonization (ICH) guidelines. UV - spectroscopic determination is carried out at an absorption maximum of 343 nm using 0.1N HCl as solvent. In the UV - spectroscopic method linearity over the concentration range of 1 20 mu g/mL with a correlation coefficient of 0.9992. Results of the analysis are validated statistically and by recovery studies. The proposed method is simple, rapid, precise and accurate and can be used for the reliable quantitation of hydroxychloroquine sulphate in bulk and pharmaceutical formulations.

引用

页码：237 / 239

页数：3

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