Novel applications of recombinant factor VIIa for the management of pediatric coagulopathic diseases

被引：11

作者：

Mathew, P ^{[1
]}

Winter, SS ^{[1
]}

Frost, JD ^{[1
]}

Hanrahan, J ^{[1
]}

Schwartz, M ^{[1
]}

Jones, JE ^{[1
]}

机构：

[1] Univ New Mexico, Dept Pediat, Albuquerque, NM 87131 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2003年 / 25卷 / 06期

关键词：

rFVIIa; bleeding; children; disseminated intravascular coagulopathy;

D O I：

10.1097/00043426-200306000-00015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recombinant factor VIIa (rFVIIa) was envisioned for the treatment of bleeding in hemophilia patients with inhibitors. In response to tissue factor expressed upon vessel wall injury, rFVIIa amplifies the thrombin burst primarily on membrane surfaces, including activated platelets. Because it is functional at a key point in the clotting cascade, rFVIIa shows promise as a therapeutic option for various bleeding situations. The prothrombin time (PT) is often used as a surrogate to monitor rFVIIa therapy. Using laboratory and clinical measures of outcome, the use of rVIIa as a therapeutic option in treating several different pediatric coagulopathic conditions is described.

引用

页码：499 / 502

页数：4

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