A chimeric Plasmodium falciparum Pfnbp2b/Pfnbp2a gene originated during asexual growth

被引：22
作者：
Cortés, A [1 ]
机构：
[1] Papua New Guinea Inst Med Res, Mol Parasitol Lab, Madang, Papua N Guinea
来源：
INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2005年 / 35卷 / 02期
关键词：
Plasmodium falciparum; invasion; gene conversion; PfNBP2b; PfRh2b; southeast Asian ovalocytosis;
D O I：
10.1016/j.ijpara.2004.11.004
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The Plasmodium falciparum line 3D7-A has an unusual invasion phenotype, such that it can invade enzyme-treated and mutant red blood cells that are resistant to invasion by other parasite lines. 3D7-A has a chimeric Pfnbp2b gene that contains part of the repeat region of the paralogous gene Pfnbp2a. This chimeric gene originated by spontaneous gene conversion during normal maintenance in culture, indicating that ectopic recombination and gene conversion during asexual growth are potentially important mechanisms participating in the evolution of paralogous genes in Plasmodium. However, the presence of the chimeric Pfnbp2b gene in 3D7-A was not associated with its peculiar invasion phenotype. (C) 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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收藏
页码：125 / 130
页数：6
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