Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

被引：16

作者：

Molina-Montes, Esther ^{[1
,2
]}

Sanchez, Maria-Jose ^{[1
,2
]}

Zamora-Ros, Raul ^{[3
]}

Bueno-de-Mesquita, H. B ^{[4
,5
,6
,7
]}

Wark, Petra A. ^{[8
]}

Obon-Santacana, Mireia ^{[9
]}

Kuehn, Tilman ^{[10
]}

Katzke, Verena ^{[10
]}

Travis, Ruth C. ^{[11
]}

Ye, Weimin ^{[12
,13
]}

Sund, Malin ^{[12
,13
]}

Naccarati, Alessio ^{[14
]}

Mattiello, Amalia ^{[15
]}

Krogh, Vittorio ^{[16
]}

Martorana, Caterina ^{[17
]}

Masala, Giovanna ^{[18
]}

Amiano, Pilar ^{[2
,19
]}

Huerta, Jose-Maria ^{[2
,20
]}

Barricarte, Aurelio ^{[2
,21
]}

Quiros, Jose-Ramon ^{[22
]}

Weiderpass, Elisabete ^{[12
,23
,24
,25
,26
]}

Asli, Lene Angell ^{[23
]}

Skeie, Guri ^{[23
]}

Ericson, Ulrika ^{[27
]}

Sonestedt, Emily ^{[27
]}

Peeters, Petra H. ^{[6
,28
]}

Romieu, Isabelle ^{[3
]}

Scalbert, Augustin ^{[3
]}

Overvad, Kim ^{[29
]}

Clemens, Matthias ^{[30
]}

Boeing, Heiner ^{[30
]}

Trichopoulou, Antonia ^{[31
,32
]}

Peppa, Eleni ^{[31
]}

Vidalis, Pavlos ^{[31
]}

Khaw, Kay-Tee ^{[33
]}

Wareham, Nick ^{[34
]}

Olsen, Anja ^{[35
]}

Tjonneland, Anne ^{[35
]}

Boutroun-Rualt, Marie-Christine ^{[36
]}

Clavel-Chapelon, Francoise ^{[36
]}

Cross, Amanda J. ^{[6
]}

Lu, Yunxia ^{[6
]}

Riboli, Elio ^{[6
]}

Duell, Eric J. ^{[9
]}

机构：

[1] Univ Granada, Hosp Univ Granada, GRANADA, Andalusian Sch Publ Hlth,Inst Invest Biosanitaria, Granada, Spain

[2] CIBERESP, CIBER Epidemiol & Salud Publ, Barcelona, Spain

[3] Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France

[4] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[5] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[6] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[7] Univ Malaya, Dept Social & Prevent Med, Fac Med, Kuala Lumpur, Malaysia

[8] Imperial Coll London, Sch Publ Hlth, Dept Primary Care & Publ Hlth, Global eHlth Unit, London, England

[9] Catalan Inst Oncol ICO Idibell, Unit Nutr & Canc, Barcelona, Spain

[10] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[11] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[12] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[13] Umea Univ, Med Biobank, Umea, Sweden

[14] HuGeF Human Genet Fdn, Mol & Genet Epidemiol Unit, Turin, Italy

[15] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[16] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[17] Canc Registry ASP, Ragusa, Italy

[18] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[19] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[20] Murcia Reg Hlth Council, Dept Epidemiol, IMIB Arrixaca, Murcia, Spain

[21] Publ Hlth Inst Navarra, Pamplona, Spain

[22] Publ Hlth Directorate, Asturias, Spain

[23] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[24] Canc Registry Norway, Dept Res, Oslo, Norway

[25] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[26] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland

[27] Lund Univ, Dept Clin Sci Malmo, Lund, Sweden

[28] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[29] Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark

[30] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[31] Hellen Hlth Fdn, Athens, Greece

[32] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Nutr & Hlth,Unit Nutr Epide, Athens, Greece

[33] Univ Cambridge, Sch Clin Med, Cambridge, England

[34] MRC, Epidemiol Unit, Cambridge, England

[35] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[36] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, Paris, France

来源：

INTERNATIONAL JOURNAL OF CANCER | 2016年 / 139卷 / 07期

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

diet; flavonoids; lignans; pancreatic cancer; cohort; POSTMENOPAUSAL WOMEN; DIETARY FLAVONOIDS; POOLED ANALYSIS; EPIC PROJECT; COUNTRIES; POPULATIONS; CATECHINS; HEALTH; COFFEE; TEA;

D O I：

10.1002/ijc.30190

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake=1.03, 95% CI: 0.95-1.11 and 1.02; 95% CI: 0.89-1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake=0.96, 95% CI: 0.91-1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort. What's new? Flavonoids and lignans found in plant-based foods are potent cancer chemopreventive agents but little is known about their effects on pancreatic cancer risk. Here the authors address this question in a large prospective epidemiological study using comprehensively derived dietary data. Their results support growing evidence that there is no association between food-based consumption of both substances with pancreatic cancer risk.

引用

页码：1480 / 1492

页数：13

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