Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

被引：16

作者：

Molina-Montes, Esther ^{[1
,2
]}

Sanchez, Maria-Jose ^{[1
,2
]}

Zamora-Ros, Raul ^{[3
]}

Bueno-de-Mesquita, H. B ^{[4
,5
,6
,7
]}

Wark, Petra A. ^{[8
]}

Obon-Santacana, Mireia ^{[9
]}

Kuehn, Tilman ^{[10
]}

Katzke, Verena ^{[10
]}

Travis, Ruth C. ^{[11
]}

Ye, Weimin ^{[12
,13
]}

Sund, Malin ^{[12
,13
]}

Naccarati, Alessio ^{[14
]}

Mattiello, Amalia ^{[15
]}

Krogh, Vittorio ^{[16
]}

Martorana, Caterina ^{[17
]}

Masala, Giovanna ^{[18
]}

Amiano, Pilar ^{[2
,19
]}

Huerta, Jose-Maria ^{[2
,20
]}

Barricarte, Aurelio ^{[2
,21
]}

Quiros, Jose-Ramon ^{[22
]}

Weiderpass, Elisabete ^{[12
,23
,24
,25
,26
]}

Asli, Lene Angell ^{[23
]}

Skeie, Guri ^{[23
]}

Ericson, Ulrika ^{[27
]}

Sonestedt, Emily ^{[27
]}

Peeters, Petra H. ^{[6
,28
]}

Romieu, Isabelle ^{[3
]}

Scalbert, Augustin ^{[3
]}

Overvad, Kim ^{[29
]}

Clemens, Matthias ^{[30
]}

Boeing, Heiner ^{[30
]}

Trichopoulou, Antonia ^{[31
,32
]}

Peppa, Eleni ^{[31
]}

Vidalis, Pavlos ^{[31
]}

Khaw, Kay-Tee ^{[33
]}

Wareham, Nick ^{[34
]}

Olsen, Anja ^{[35
]}

Tjonneland, Anne ^{[35
]}

Boutroun-Rualt, Marie-Christine ^{[36
]}

Clavel-Chapelon, Francoise ^{[36
]}

Cross, Amanda J. ^{[6
]}

Lu, Yunxia ^{[6
]}

Riboli, Elio ^{[6
]}

Duell, Eric J. ^{[9
]}

机构：

[1] Univ Granada, Hosp Univ Granada, GRANADA, Andalusian Sch Publ Hlth,Inst Invest Biosanitaria, Granada, Spain

[2] CIBERESP, CIBER Epidemiol & Salud Publ, Barcelona, Spain

[3] Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France

[4] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[5] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[6] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[7] Univ Malaya, Dept Social & Prevent Med, Fac Med, Kuala Lumpur, Malaysia

[8] Imperial Coll London, Sch Publ Hlth, Dept Primary Care & Publ Hlth, Global eHlth Unit, London, England

[9] Catalan Inst Oncol ICO Idibell, Unit Nutr & Canc, Barcelona, Spain

[10] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[11] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[12] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[13] Umea Univ, Med Biobank, Umea, Sweden

[14] HuGeF Human Genet Fdn, Mol & Genet Epidemiol Unit, Turin, Italy

[15] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[16] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[17] Canc Registry ASP, Ragusa, Italy

[18] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[19] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[20] Murcia Reg Hlth Council, Dept Epidemiol, IMIB Arrixaca, Murcia, Spain

[21] Publ Hlth Inst Navarra, Pamplona, Spain

[22] Publ Hlth Directorate, Asturias, Spain

[23] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[24] Canc Registry Norway, Dept Res, Oslo, Norway

[25] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[26] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland

[27] Lund Univ, Dept Clin Sci Malmo, Lund, Sweden

[28] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[29] Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark

[30] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[31] Hellen Hlth Fdn, Athens, Greece

[32] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Nutr & Hlth,Unit Nutr Epide, Athens, Greece

[33] Univ Cambridge, Sch Clin Med, Cambridge, England

[34] MRC, Epidemiol Unit, Cambridge, England

[35] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[36] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, Paris, France

来源：

INTERNATIONAL JOURNAL OF CANCER | 2016年 / 139卷 / 07期

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

diet; flavonoids; lignans; pancreatic cancer; cohort; POSTMENOPAUSAL WOMEN; DIETARY FLAVONOIDS; POOLED ANALYSIS; EPIC PROJECT; COUNTRIES; POPULATIONS; CATECHINS; HEALTH; COFFEE; TEA;

D O I：

10.1002/ijc.30190

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake=1.03, 95% CI: 0.95-1.11 and 1.02; 95% CI: 0.89-1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake=0.96, 95% CI: 0.91-1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort. What's new? Flavonoids and lignans found in plant-based foods are potent cancer chemopreventive agents but little is known about their effects on pancreatic cancer risk. Here the authors address this question in a large prospective epidemiological study using comprehensively derived dietary data. Their results support growing evidence that there is no association between food-based consumption of both substances with pancreatic cancer risk.

引用

页码：1480 / 1492

页数：13

共 50 条

[21] Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition
Merritt, Melissa A.
Riboli, Elio
Weiderpass, Elisabete
Tsilidis, Konstantinos K.
Overvad, Kim
Tjonneland, Anne
Hansen, Louise
Dossus, Laure
Fagherazzi, Guy
Baglietto, Laura
Fortner, Renee T.
Ose, Jennifer
Steffen, Annika
Boeing, Heiner
Trichopoulou, Antonia
Trichopoulos, Dimitrios
Lagiou, Pagona
Masala, Giovanna
Sieri, Sabina
Mattiello, Amalia
Tumino, Rosario
Sacerdote, Carlotta
Bueno-de-Mesquita, H. B
Onland-Moret, N. Charlotte
Peeters, Petra H.
Hjartaker, Anette
Gram, Inger Torhild
Ramon Quiros, J.
Obon-Santacana, Mireia
Molina-Montes, Esther
Huerta Castano, Jose Maria
Ardanaz, Eva
Chamosa, Saioa
Sonestedt, Emily
Idahl, Annika
Lundin, Eva
Khaw, Kay-Tee
Wareham, Nicholas
Travis, Ruth C.
Rinaldi, Sabina
Romieu, Isabelle
Chajes, Veronique
Gunter, Marc J.
CANCER EPIDEMIOLOGY, 2014, 38 (05) : 528 - 537
[22] Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
Obon-Santacana, M.
Kaaks, R.
Slimani, N.
Lujan-Barroso, L.
Freisling, H.
Ferrari, P.
Dossus, L.
Chabbert-Buffet, N.
Baglietto, L.
Fortner, R. T.
Boeing, H.
Tjonneland, A.
Olsen, A.
Overvad, K.
Menendez, V.
Molina-Montes, E.
Larranaga, N.
Chirlaque, M-D
Ardanaz, E.
Khaw, K-T
Wareham, N.
Travis, R. C.
Lu, Y.
Merritt, M. A.
Trichopoulou, A.
Benetou, V.
Trichopoulos, D.
Saieva, C.
Sieri, S.
Tumino, R.
Sacerdote, C.
Galasso, R.
Bueno-de-Mesquita, H. B.
Wirfalt, E.
Ericson, U.
Idahl, A.
Ohlson, N.
Skeie, G.
Gram, I. T.
Weiderpass, E.
Onland-Moret, N. C.
Riboli, E.
Duell, E. J.
BRITISH JOURNAL OF CANCER, 2014, 111 (05) : 987 - 997
[23] Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
Lujan-Barroso, Leila
Alberto Gonzalez, Carlos
Slimani, Nadia
Obon-Santacana, Mireia
Ferrari, Pietro
Freisling, Heinz
Overvad, Kim
Clavel-Chapelon, Francoise
Boutron-Ruault, Marie-Christine
Racine, Antoine
Katzke, Verena
Kuehn, Tilman
Tjonneland, Anne
Olsen, Anja
Ramon Quiros, J.
Sanchez-Cantalejo, Emilio
Amiano, Pilar
Navarro, Carmen
Barricarte, Aurelio
Khaw, Kay-Tee
Wareham, Nick
Travis, Ruth C.
Trichopoulou, Antonia
Bamia, Christina
Benetou, Vassiliki
Saieva, Calogero
Grioni, Sara
Tumino, Rosario
Vineis, Paolo
Mattiello, Amalia
Bueno-de-Mesquita, H. Bas
Siersema, Peter D.
Numans, Mattijs E.
Peeters, Petra H.
Ericson, Ulrika
Wirfaelt, Elisabet
Sund, Malin
Johansson, Mattias
Weiderpass, Elisabete
Skeie, Guri
Riboli, Elio
Boeing, Heiner
Duell, Eric J.
CANCER CAUSES & CONTROL, 2014, 25 (05) : 639 - 646
[24] Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Zamora-Ros, Raul
Cayssials, Valerie
Jenab, Mazda
Rothwell, Joseph A.
Fedirko, Veronika
Aleksandrova, Krasimira
Tjonneland, Anne
Kyro, Cecilie
Overvad, Kim
Boutron-Ruault, Marie-Christine
Carbonnel, Franck
Mahamat-Saleh, Yahya
Kaaks, Rudolf
Kuehn, Tilman
Boeing, Heiner
Trichopoulou, Antonia
Valanou, Elissavet
Vasilopoulou, Effie
Masala, Giovanna
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Ricceri, Fulvio
Weiderpass, Elisabete
Lukic, Marko
Sandanger, Torkjel M.
Lasheras, Cristina
Agudo, Antonio
Sanchez, Maria-Jose
Amiano, Pilar
Navarro, Carmen
Ardanaz, Eva
Sonestedt, Emily
Ohlsson, Bodil
Nilsson, Lena Maria
Rutegard, Martin
Bueno-de-Mesquita, Bas
Peeters, Petra H.
Khaw, Kay-Thee
Wareham, Nicholas J.
Bradbury, Kathryn
Freisling, Heinz
Romieu, Isabelle
Cross, Amanda J.
Vineis, Paolo
Scalbert, Augustin
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2018, 33 (11) : 1063 - 1075
[25] Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
Londono, Catalina
Cayssials, Valerie
de Villasante, Izar
Crous-Bou, Marta
Scalbert, Augustin
Weiderpass, Elisabete
Agudo, Antonio
Tjonneland, Anne
Olsen, Anja
Overvad, Kim
Katzke, Verena
Schulze, Matthias
Palli, Domenico
Krogh, Vittorio
de Magistris, Maria Santucci
Tumino, Rosario
Ricceri, Fulvio
Gram, Inger T.
Rylander, Charlotta
Skeie, Guri
Sanchez, Maria-Jose
Amiano, Pilar
Maria Huerta, Jose
Barricarte, Aurelio
Sartor, Hanna
Sonestedt, Emily
Esberg, Anders
Idahl, Annika
Mahamat-Saleh, Yahya
Laouali, Nasser
Kvaskoff, Marina
Turzanski-Fortner, Renee
Zamora-Ros, Raul
ANTIOXIDANTS, 2021, 10 (08)
[26] Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Ward, Heather A.
Whitman, Julia
Muller, David C.
Johansson, Mattias
Jakszyn, Paula
Weiderpass, Elisabete
Palli, Domenico
Fanidi, Anouar
Vermeulen, Roel
Tjonneland, Anne
Hansen, Louise
Dahm, Christina C.
Overvad, Kim
Severi, Gianluca
Boutron-Ruault, Marie-Christine
Affret, Aurelie
Kaaks, Rudolf
Fortner, Renee
Boeing, Heiner
Trichopoulou, Antonia
La Vecchia, Carlo
Kotanidou, Anastasia
Berrino, Franco
Krogh, Vittorio
Tumino, Rosario
Ricceri, Fulvio
Panico, Salvatore
Bueno-de-Mesquita, H. Bas
Peeters, Petra H.
Nost, Therese Haugdahl
Sandanger, Torkjel M.
Ramon Quiros, Jose
Agudo, Antonio
Rodriguez-Barranco, Miguel
Larranaga, Nerea
Maria Huerta, Jose
Ardanaz, Eva
Drake, Isabel
Brunnstrom, Hans
Johansson, Mikael
Grankvist, Kjell
Travis, Ruth C.
Freisling, Heinz
Stepien, Magdalena
Merritt, Melissa A.
Riboli, Elio
Cross, Amanda J.
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2019, 73 (08) : 1122 - 1132
[27] Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
Vrieling, Alina
Verhage, Bas A. J.
van Duijnhoven, Franzel J. B.
Jenab, Mazda
Overvad, Kim
Tjonneland, Anne
Olsen, Anja
Clavel-Chapelon, Francoise
Boutron-Ruault, Marie-Christine
Kaaks, Rudolf
Rohrmann, Sabine
Boeing, Heiner
Noethlings, Ute
Trichopoulou, Antonia
John, Tountas
Dimosthenes, Zilis
Palli, Domenico
Sieri, Sabina
Mattielllo, Amalia
Tumino, Rosario
Vineis, Paolo
van Gils, Carla H.
Peeters, Petra H. M.
Engeset, Dagrun
Lund, Eiliv
Rodriguez Suarez, Laudina
Jakszyn, Paula
Larranaga, Nerea
Sanchez, Maria-Jose
Chirlaque, Maria-Dolores
Ardana, Eva
Manjer, Jonas
Lindkvist, Bjoern
Hallmans, Goeran
Ye, Weimin
Bingham, Sheila
Khaw, Kay-Tee
Roddam, Andrew
Key, Tim
Boffetta, Paolo
Duell, Eric J.
Michaud, Dominique S.
Riboli, Elio
Bueno-de-Mesquita, H. Bas
INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (08) : 1926 - 1934
[28] Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Perez-Cornago, Aurora
Travis, Ruth C.
Appleby, Paul N.
Tsilidis, Konstantinos K.
Tjonneland, Anne
Olsen, Anja
Overvad, Kim
Katzke, Verena
Kuehn, Tilman
Trichopoulou, Antonia
Peppa, Eleni
Kritikou, Maria
Sieri, Sabina
Palli, Domenico
Sacerdote, Carlotta
Tumino, Rosario
Bueno-de-Mesquita, H. B.
Agudo, Antonio
Larranaga, Nerea
Molina-Portillo, Elena
Ardanaz, Eva
Chirlaque, Maria-Dolores
Lasheras, Cristina
Stattin, Par
Wennberg, Maria
Drake, Isabel
Malm, Johan
Schmidt, Julie A.
Khaw, Kay-Tee
Gunter, Marc
Freisling, Heinz
Huybrechts, Inge
Aune, Dagfinn
Cross, Amanda J.
Riboli, Elio
Key, Timothy J.
INTERNATIONAL JOURNAL OF CANCER, 2017, 141 (02) : 287 - 297
[29] DIETARY INTAKE OF ACRYLAMIDE AND OESOPHAGEAL CANCER (OC) RISK IN THE EUROPEAN PROSPECTIVE INVESTIGATION INTO CANCER AND NUTRITION (EPIC) COHORT
Lujan-Barroso, L.
Duell, E. J.
Obon-Santacana, M.
Slimani, N.
Boeing, H.
Gonzalez, C. A.
ANNALS OF NUTRITION AND METABOLISM, 2013, 63 : 1203 - 1203
[30] Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Kyro, Cecilie
Zamora-Ros, Raul
Scalbert, Augustin
Tjonneland, Anne
Dossus, Laure
Johansen, Christoffer
Bidstrup, Pernille Envold
Weiderpass, Elisabete
Christensen, Jane
Ward, Heather
Aune, Dagfinn
Riboli, Elio
His, Mathilde
Clavel-Chapelon, Francoise
Baglietto, Laura
Katzke, Verena
Kuehn, Tilman
Boeing, Heiner
Floegel, Anna
Overvad, Kim
Lasheras, Cristina
Travier, Noemie
Sanchez, Maria-Jose
Amiano, Pilar
Chirlaque, Maria-Dolores
Ardanaz, Eva
Khaw, Kay-Tee
Wareham, Nick
Perez-Cornago, Aurora
Trichopoulou, Antonia
Lagiou, Pagona
Vasilopoulou, Effie
Masala, Giovanna
Grioni, Sara
Berrino, Franco
Tumino, Rosario
Sacerdote, Carlotta
Mattiello, Amalia
Bueno-de-Mesquita, H. B.
Peeters, Petra H.
van Gils, Carla
Borgquist, Signe
Butt, Salma
Zeleniuch-Jacquotte, Anne
Sund, Malin
Hjartaker, Anette
Skeie, Guri
Olsen, Anja
Romieu, Isabelle
BREAST CANCER RESEARCH AND TREATMENT, 2015, 154 (02) : 389 - 401

← 1 2 3 4 5 →