Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

被引：16

作者：

Molina-Montes, Esther ^{[1
,2
]}

Sanchez, Maria-Jose ^{[1
,2
]}

Zamora-Ros, Raul ^{[3
]}

Bueno-de-Mesquita, H. B ^{[4
,5
,6
,7
]}

Wark, Petra A. ^{[8
]}

Obon-Santacana, Mireia ^{[9
]}

Kuehn, Tilman ^{[10
]}

Katzke, Verena ^{[10
]}

Travis, Ruth C. ^{[11
]}

Ye, Weimin ^{[12
,13
]}

Sund, Malin ^{[12
,13
]}

Naccarati, Alessio ^{[14
]}

Mattiello, Amalia ^{[15
]}

Krogh, Vittorio ^{[16
]}

Martorana, Caterina ^{[17
]}

Masala, Giovanna ^{[18
]}

Amiano, Pilar ^{[2
,19
]}

Huerta, Jose-Maria ^{[2
,20
]}

Barricarte, Aurelio ^{[2
,21
]}

Quiros, Jose-Ramon ^{[22
]}

Weiderpass, Elisabete ^{[12
,23
,24
,25
,26
]}

Asli, Lene Angell ^{[23
]}

Skeie, Guri ^{[23
]}

Ericson, Ulrika ^{[27
]}

Sonestedt, Emily ^{[27
]}

Peeters, Petra H. ^{[6
,28
]}

Romieu, Isabelle ^{[3
]}

Scalbert, Augustin ^{[3
]}

Overvad, Kim ^{[29
]}

Clemens, Matthias ^{[30
]}

Boeing, Heiner ^{[30
]}

Trichopoulou, Antonia ^{[31
,32
]}

Peppa, Eleni ^{[31
]}

Vidalis, Pavlos ^{[31
]}

Khaw, Kay-Tee ^{[33
]}

Wareham, Nick ^{[34
]}

Olsen, Anja ^{[35
]}

Tjonneland, Anne ^{[35
]}

Boutroun-Rualt, Marie-Christine ^{[36
]}

Clavel-Chapelon, Francoise ^{[36
]}

Cross, Amanda J. ^{[6
]}

Lu, Yunxia ^{[6
]}

Riboli, Elio ^{[6
]}

Duell, Eric J. ^{[9
]}

机构：

[1] Univ Granada, Hosp Univ Granada, GRANADA, Andalusian Sch Publ Hlth,Inst Invest Biosanitaria, Granada, Spain

[2] CIBERESP, CIBER Epidemiol & Salud Publ, Barcelona, Spain

[3] Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France

[4] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[5] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[6] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[7] Univ Malaya, Dept Social & Prevent Med, Fac Med, Kuala Lumpur, Malaysia

[8] Imperial Coll London, Sch Publ Hlth, Dept Primary Care & Publ Hlth, Global eHlth Unit, London, England

[9] Catalan Inst Oncol ICO Idibell, Unit Nutr & Canc, Barcelona, Spain

[10] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[11] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[12] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[13] Umea Univ, Med Biobank, Umea, Sweden

[14] HuGeF Human Genet Fdn, Mol & Genet Epidemiol Unit, Turin, Italy

[15] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[16] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[17] Canc Registry ASP, Ragusa, Italy

[18] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[19] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[20] Murcia Reg Hlth Council, Dept Epidemiol, IMIB Arrixaca, Murcia, Spain

[21] Publ Hlth Inst Navarra, Pamplona, Spain

[22] Publ Hlth Directorate, Asturias, Spain

[23] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[24] Canc Registry Norway, Dept Res, Oslo, Norway

[25] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[26] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland

[27] Lund Univ, Dept Clin Sci Malmo, Lund, Sweden

[28] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[29] Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark

[30] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[31] Hellen Hlth Fdn, Athens, Greece

[32] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Nutr & Hlth,Unit Nutr Epide, Athens, Greece

[33] Univ Cambridge, Sch Clin Med, Cambridge, England

[34] MRC, Epidemiol Unit, Cambridge, England

[35] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[36] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, Paris, France

来源：

INTERNATIONAL JOURNAL OF CANCER | 2016年 / 139卷 / 07期

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

diet; flavonoids; lignans; pancreatic cancer; cohort; POSTMENOPAUSAL WOMEN; DIETARY FLAVONOIDS; POOLED ANALYSIS; EPIC PROJECT; COUNTRIES; POPULATIONS; CATECHINS; HEALTH; COFFEE; TEA;

D O I：

10.1002/ijc.30190

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake=1.03, 95% CI: 0.95-1.11 and 1.02; 95% CI: 0.89-1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake=0.96, 95% CI: 0.91-1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort. What's new? Flavonoids and lignans found in plant-based foods are potent cancer chemopreventive agents but little is known about their effects on pancreatic cancer risk. Here the authors address this question in a large prospective epidemiological study using comprehensively derived dietary data. Their results support growing evidence that there is no association between food-based consumption of both substances with pancreatic cancer risk.

引用

页码：1480 / 1492

页数：13

共 50 条

[1] Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Zamora-Ros, R.
Sacerdote, C.
Ricceri, F.
Weiderpass, E.
Roswall, N.
Buckland, G.
St-Jules, D. E.
Overvad, K.
Kyro, C.
Fagherazzi, G.
Kvaskoff, M.
Severi, G.
Chang-Claude, J.
Kaaks, R.
Noethlings, U.
Trichopoulou, A.
Naska, A.
Trichopoulos, D.
Palli, D.
Grioni, S.
Mattiello, A.
Tumino, R.
Gram, I. T.
Engeset, D.
Huerta, J. M.
Molina-Montes, E.
Argueelles, M.
Amiano, P.
Ardanaz, E.
Ericson, U.
Lindkvist, B.
Nilsson, L. M.
Kiemeney, L. A.
Ros, M.
Bueno-de-Mesquita, H. B.
Peeters, P. H. M.
Khaw, K-T
Wareham, N. J.
Knaze, V.
Romieu, I.
Scalbert, A.
Brennan, P.
Wark, P.
Vineis, P.
Riboli, E.
Gonzalez, C. A.
BRITISH JOURNAL OF CANCER, 2014, 111 (09) : 1870 - 1880
[2] Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort
Zamora-Ros, Raul
Barupal, Dinesh K.
Rothwell, Joseph A.
Jenab, Mazda
Fedirko, Veronika
Romieu, Isabelle
Aleksandrova, Krasimira
Overvad, Kim
Kyro, Cecilie
Tjonneland, Anne
Affret, Aurelie
His, Mathilde
Boutron-Ruault, Marie-Christine
Katzke, Verena
Kuehn, Tilman
Boeing, Heiner
Trichopoulou, Antonia
Naska, Androniki
Kritikou, Maria
Saieva, Calogero
Agnoli, Claudia
de Magistris, Maria Santucci
Tumino, Rosario
Fasanelli, Francesca
Weiderpass, Elisabete
Skeie, Guri
Merino, Susana
Jakszyn, Paula
Sanchez, Maria-Jose
Dorronsoro, Miren
Navarro, Carmen
Ardanaz, Eva
Sonestedt, Emily
Ericson, Ulrika
Nilsson, Lena Maria
Boden, Stina
Bueno-de-Mesquita, H. B.
Peeters, Petra H.
Perez-Cornago, Aurora
Wareham, Nicholas J.
Khaw, Kay-Thee
Freisling, Heinz
Cross, Amanda J.
Riboli, Elio
Scalbert, Augustin
INTERNATIONAL JOURNAL OF CANCER, 2017, 140 (08) : 1836 - 1844
[3] Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
R Zamora-Ros
C Sacerdote
F Ricceri
E Weiderpass
N Roswall
G Buckland
D E St-Jules
K Overvad
C Kyrø
G Fagherazzi
M Kvaskoff
G Severi
J Chang-Claude
R Kaaks
U Nöthlings
A Trichopoulou
A Naska
D Trichopoulos
D Palli
S Grioni
A Mattiello
R Tumino
I T Gram
D Engeset
J M Huerta
E Molina-Montes
M Argüelles
P Amiano
E Ardanaz
U Ericson
B Lindkvist
L M Nilsson
L A Kiemeney
M Ros
H B Bueno-de-Mesquita
P H M Peeters
K-T Khaw
N J Wareham
V Knaze
I Romieu
A Scalbert
P Brennan
P Wark
P Vineis
E Riboli
C A González
British Journal of Cancer, 2014, 111 : 1870 - 1880
[4] Dietary intake of acrylamide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Obon-Santacana, M.
Slimani, N.
Lujan-Barroso, L.
Travier, N.
Hallmans, G.
Freisling, H.
Ferrari, P.
Boutron-Ruault, M. C.
Racine, A.
Clavel, F.
Saieva, C.
Pala, V.
Tumino, R.
Mattiello, A.
Vineis, P.
Argueelles, M.
Ardanaz, E.
Amiano, P.
Navarro, C.
Sanchez, M. J.
Montes, E. Molina
Key, T.
Khaw, K. -T.
Wareham, N.
Peeters, P. H.
Trichopoulou, A.
Bamia, C.
Trichopoulos, D.
Boeing, H.
Kaaks, R.
Katzke, V.
Ye, W.
Sund, M.
Ericson, U.
Wirfalt, E.
Overvad, K.
Tjonneland, A.
Olsen, A.
Skeie, G.
Asli, L. A.
Weiderpass, E.
Riboli, E.
Bueno-De-Mesquita, H. B.
Duell, E. J.
ANNALS OF ONCOLOGY, 2013, 24 (10) : 2645 - 2651
[5] Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
Zamora-Ros, Raul
Ferrari, Pietro
Gonzalez, Carlos A.
Tjonneland, Anne
Olsen, Anja
Bredsdorff, Lea
Overvad, Kim
Touillaud, Marina
Perquier, Florence
Fagherazzi, Guy
Lukanova, Annekatrin
Tikk, Kaja
Aleksandrova, Krasimira
Boeing, Heiner
Trichopoulou, Antonia
Trichopoulos, Dimitrios
Dilis, Vardis
Masala, Giovanna
Sieri, Sabina
Mattiello, Amalia
Tumino, Rosario
Ricceri, Fulvio
Bueno-de-Mesquita, H. Bas
Peeters, Petra H. M.
Weiderpass, Elisabete
Skeie, Guri
Engeset, Dagrun
Menendez, Virginia
Travier, Noemie
Molina-Montes, Esther
Amiano, Pilar
Chirlaque, Maria-Dolores
Barricarte, Aurelio
Wallstrom, Peter
Sonestedt, Emily
Sund, Malin
Landberg, Rikard
Khaw, Kay-Thee
Wareham, Nicholas J.
Travis, Ruth C.
Scalbert, Augustin
Ward, Heather A.
Riboli, Elio
Romieu, Isabelle
BREAST CANCER RESEARCH AND TREATMENT, 2013, 139 (01) : 163 - 176
[6] Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort
Vermeulen, Esther
Zamora-Ros, Raul
Duell, Eric J.
Lujan-Barroso, Leila
Boeing, Heiner
Aleksandrova, Krasimira
Bueno-de-Mesquita, H. Bas
Scalbert, Augustin
Romieu, Isabelle
Fedirko, Veronika
Touillaud, Marina
Fagherazzi, Guy
Perquier, Florence
Molina-Montes, Esther
Chirlaque, Maria-Dolores
Argueelles, Marcial Vicente
Amiano, Pilar
Barricarte, Aurelio
Pala, Valeria
Mattiello, Amalia
Saieva, Calogero
Tumino, Rosario
Ricceri, Fulvio
Trichopoulou, Antonia
Vasilopoulou, Effie
Ziara, Gianna
Crowe, Francesca L.
Khaw, Kay-Thee
Wareham, Nicholas J.
Vasilopoulou, Effie
Ziara, Gianna
Crowe, Francesca L.
Khaw, Kay-Thee
Wareham, Nicholas J.
Lukanova, Annekatrin
Grote, Verena A.
Tjonneland, Anne
Halkjaer, Jytte
Bredsdorff, Lea
Overvad, Kim
Siersema, Peter D.
Peeters, Petra H. M.
May, Anne M.
Weiderpass, Elisabete
Skeie, Guri
Hjartaker, Anette
Landberg, Rikard
Johansson, Ingegerd
Sonestedt, Emily
Ericson, Ulrika
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2013, 178 (04) : 570 - 581
[7] Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Zamora-Ros, Raul
Agudo, Antonio
Lujan-Barroso, Leila
Romieu, Isabelle
Ferrari, Pietro
Knaze, Viktoria
Bueno-de-Mesquita, H. Bas
Leenders, Max
Travis, Ruth C.
Navarro, Carmen
Sanchez-Cantalejo, Emilio
Slimani, Nadia
Scalbert, Augustin
Fedirko, Veronika
Hjartaker, Anette
Engeset, Dagrun
Skeie, Guri
Boeing, Heiner
Foerster, Jana
Li, Kuanrong
Teuchet, Birgit
Agnoli, Claudia
Tumino, Rosario
Mattiello, Amalia
Saieva, Calogero
Johansson, Ingegerd
Stenling, Roger
Luisa Redondo, Maria
Wallstrom, Peter
Ericson, Ulrika
Khaw, Kay-Tee
Mulligan, Angela A.
Trichopoulou, Antonia
Dilis, Vardis
Katsoulis, Michael
Peeters, Petra H. M.
Igali, Lazslo
Tjonneland, Anne
Halkjaer, Jytte
Touillaud, Marina
Perquier, Florence
Fagherazzi, Guy
Amiano, Pilar
Ardanaz, Eva
Bredsdorff, Lea
Overvad, Kim
Ricceri, Fulvio
Riboli, Elio
Gonzalez, Carlos A.
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 96 (06) : 1398 - 1408
[8] Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study
Zamora-Ros, Raul
Fedirko, Veronika
Trichopoulou, Antonia
Gonzalez, Carlos A.
Bamia, Christina
Trepo, Elisabeth
Noethlings, Ute
Duarte-Salles, Talita
Serafini, Mauro
Bredsdorff, Lea
Overvad, Kim
Tjonneland, Anne
Halkjaer, Jytte
Fagherazzi, Guy
Perquier, Florence
Boutron-Ruault, Marie-Christine
Katzke, Verena
Lukanova, Annekatrin
Floegel, Anna
Boeing, Heiner
Lagiou, Pagona
Trichopoulos, Dimitrios
Saieva, Calogero
Agnoli, Claudia
Mattiello, Amalia
Tumino, Rosario
Sacerdote, Carlotta
Bueno-de-Mesquita, H. Bas
Peeters, Petra H. M.
Weiderpass, Elisabete
Engeset, Dagrun
Skeie, Guri
Argueelles, Marcial Vicente
Molina-Montes, Esther
Dorronsoro, Miren
Tormo, Maria Jose
Ardanaz, Eva
Ericson, Ulrika
Sonestedt, Emily
Sund, Malin
Landberg, Rikard
Khaw, Kay-Tee
Wareham, Nicholas J.
Crowe, Francesca L.
Riboli, Elio
Jenab, Mazda
INTERNATIONAL JOURNAL OF CANCER, 2013, 133 (10) : 2429 - 2443
[9] Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort
Molina-Montes, Esther
Wark, Petra A.
Sanchez, Maria-Jose
Norat, Teresa
Jakszyn, Paula
Lujan-Barroso, Leila
Michaud, Dominique S.
Crowe, Francesca
Allen, Naomi
Khaw, Kay-Tee
Wareham, Nicholas
Trichopoulou, Antonia
Adarakis, George
Katarachia, Helen
Skeie, Guri
Henningsen, Maria
Broderstad, Ann Ragnhild
Berrino, Franco
Tumino, Rosario
Palli, Domenico
Mattiello, Amalia
Vineis, Paolo
Amiano, Pilar
Barricarte, Aurelio
Huerta, Jose-Maria
Duell, Eric J.
Quiros, Jose-Ramon
Ye, Weimin
Sund, Malin
Lindkvist, Bjorn
Johansen, Dorthe
Overvad, Kim
Tjonneland, Anne
Roswall, Nina
Li, Kuanrong
Grote, Verena A.
Steffen, Annika
Boeing, Heiner
Racine, Antoine
Boutron-Ruault, Marie-Christine
Carbonnel, Franck
Peeters, Petra H. M.
Siersema, Peter D.
Fedirko, Veronika
Jenab, Mazda
Riboli, Elio
Bueno-de-Mesquita, Bas
INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (07) : E1134 - E1147
[10] DIETARY INTAKE OF ACRYLAMIDE AND PANCREATIC CANCER RISK IN THE EUROPEAN PROSPECTIVE INVESTIGATION INTO CANCER AND NUTRITION (EPIC) COHORT
Obon-Santacana, M.
Lujan-Barroso, L.
Slimani, N.
Bueno-de-Mesquita, H. B.
Duell, E. J.
ANNALS OF NUTRITION AND METABOLISM, 2013, 63 : 1204 - 1204

← 1 2 3 4 5 →