Recent Advances in Aptamer-Based Liquid Biopsy

被引：23

作者：

Zhang, Jialu ^{[1
]}

Huang, Yihao ^{[1
]}

Sun, Miao ^{[1
]}

Wan, Shuang ^{[1
]}

Yang, Chaoyong ^{[1
,2
]}

Song, Yanling ^{[1
]}

机构：

[1] Xiamen Univ, Dept Chem Biol, MOE Key Lab Spectrochem Anal & Instrumentat, State Key Lab Phys Chem Solid Surfaces,Coll Chem, Xiamen 361005, Peoples R China

[2] Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med, Sch Med, Shanghai 200127, Peoples R China

来源：

ACS APPLIED BIO MATERIALS | 2022年 / 5卷 / 05期

基金：

中国国家自然科学基金;

关键词：

aptamer; selection; liquid biopsy; circulating tumor cells; extracellular vesicles; CIRCULATING TUMOR-CELLS; QUANTITATIVE SCREENING METHOD; HIGHLY EFFICIENT CAPTURE; CANCER-CELLS; HIGH-AFFINITY; DNA APTAMERS; ELECTROCHEMICAL DETECTION; ULTRASENSITIVE CAPTURE; MOLECULAR RECOGNITION; PARTICLE DISPLAY;

D O I：

10.1021/acsabm.1c01202

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Liquid biopsy capable of noninvasive and real-time molecular profiling is considered as a breakthrough technology, endowing an opportunity for precise diagnosis of individual patients. Extracellular vesicles (EVs) and circulating tumor cells (CTCs) consisting of substantial disease-related molecular information play an important role in liquid biopsy. Therefore, it is critically significant to exploit high-performance recognition ligands for efficient isolation and analysis of EVs and CTCs from complex body fluids. Aptamers exhibit extraordinary merits of high specificity and affinity, which are considered as superior recognition ligands for liquid biopsy. In this review, we first summarize recent advanced strategies for the evolution of high-performance aptamers and the construction of various aptamer-based recognition elements. Subsequently, we mainly discuss the isolation and analysis of EVs and CTCs based on the aptamer functioned biomaterials/biointerface. Ultimately, we envision major challenges and future direction of aptamer-based liquid biopsy for clinical utilities.

引用

页码：1954 / 1979

页数：26

共 161 条

[41] Identification of sequence-structure RNA binding motifs for SELEX-derived aptamers [J].

Hoinka, Jan ;

Zotenko, Elena ;

Friedman, Adam ;

Sauna, Zuben E. ;

Przytycka, Teresa M. .

BIOINFORMATICS, 2012, 28 (12) :I215-I223

[42] Multifunctional Screening Platform for the Highly Efficient Discovery of Aptamers with High Affinity and Specificity [J].

Hong, Shao-Li ;

Wan, Ya-Tao ;

Tang, Man ;

Pang, Dai-Wen ;

Zhang, Zhi-Ling .

ANALYTICAL CHEMISTRY, 2017, 89 (12) :6535-6542

[43] ADAPT identifies an ESCRT complex composition that discriminates VCaP from LNCaP prostate cancer cell exosomes [J].

Hornung, Tassilo ;

O'Neill, Heather A. ;

Logie, Stephen C. ;

Fowler, Kimberly M. ;

Duncan, Janet E. ;

Rosenow, Matthew ;

Bondre, Aniket S. ;

Tinder, Teresa ;

Maher, Varun ;

Zarkovic, Jelena ;

Zhong, Zenyu ;

Richards, Melissa N. ;

Wei, Xixi ;

Miglarese, Mark R. ;

Mayer, Gunter ;

Famulok, Michael ;

Spetzler, David .

NUCLEIC ACIDS RESEARCH, 2020, 48 (08) :4013-4027

[44] Activation of Aptamers with Gain of Function by Small-Molecule-Clipping of Intramolecular Motifs [J].

Huang, Mengjiao ;

Li, Tingyu ;

Xu, Yuanfeng ;

Wei, Xinyu ;

Song, Jia ;

Lin, Bingqian ;

Zhu, Zhi ;

Song, Yanling ;

Yang, Chaoyong .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (11) :6021-6028

[45] Homogeneous, Low-volume, Efficient, and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction [J].

Huang, Mengjiao ;

Yang, Juanjuan ;

Wang, Teng ;

Song, Jia ;

Xia, Jinglu ;

Wu, Lingling ;

Wang, Wei ;

Wu, Qiaoyi ;

Zhu, Zhi ;

Song, Yanling ;

Yang, Chaoyong .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (12) :4800-4805

[46] Molecular Crowding Evolution for Enabling Discovery of Enthalpy-Driven Aptamers for Robust Biomedical Applications [J].

Huang, Mengjiao ;

Song, Jia ;

Huang, Peifeng ;

Chen, Xiaofeng ;

Wang, Wei ;

Zhu, Zhi ;

Song, Yanling ;

Yang, Chaoyong .

ANALYTICAL CHEMISTRY, 2019, 91 (16) :10879-10886

[47] Localized Chemical Remodeling for Live Cell Imaging of Protein-Specific Glycoform [J].

Hui, Jingjing ;

Bao, Lei ;

Li, Siqiao ;

Zhang, Yi ;

Feng, Yimei ;

Ding, Lin ;

Ju, Huangxian .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (28) :8139-8143

[48] Aptamer/AuNP Biosensor for Colorimetric Profiling of Exosomal Proteins [J].

Jiang, Ying ;

Shi, Muling ;

Liu, Yuan ;

Wan, Shuo ;

Cui, Cheng ;

Zhang, Liqin ;

Tan, Weihong .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (39) :11916-11920

[49] Multivalence-Actuated DNA Nanomachines Enable Bicolor Exosomal Phenotyping and PD-L1-Guided Therapy Monitoring [J].

Jin, Dan ;

Peng, Xin-Xin ;

Qin, You ;

Wu, Peng ;

Lu, Hao ;

Wang, Liangchao ;

Huang, Jing ;

Li, Yuting ;

Zhang, Yulin ;

Zhang, Guo-Jun ;

Yang, Fan .

ANALYTICAL CHEMISTRY, 2020, 92 (14) :9877-9886

[50] ExoAPP: Exosome-Oriented, Aptamer Nanoprobe-Enabled Surface Proteins Profiling and Detection [J].

Jin, Dan ;

Yang, Fan ;

Zhang, Yulin ;

Liu, Li ;

Zhou, Yujuan ;

Wang, Fubing ;

Zhang, Guo-Jun .

ANALYTICAL CHEMISTRY, 2018, 90 (24) :14402-14411

← 1 2 3 4 5 6 7 8 9 10 →