Recent Advances in Aptamer-Based Liquid Biopsy

被引：23

作者：

Zhang, Jialu ^{[1
]}

Huang, Yihao ^{[1
]}

Sun, Miao ^{[1
]}

Wan, Shuang ^{[1
]}

Yang, Chaoyong ^{[1
,2
]}

Song, Yanling ^{[1
]}

机构：

[1] Xiamen Univ, Dept Chem Biol, MOE Key Lab Spectrochem Anal & Instrumentat, State Key Lab Phys Chem Solid Surfaces,Coll Chem, Xiamen 361005, Peoples R China

[2] Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med, Sch Med, Shanghai 200127, Peoples R China

来源：

ACS APPLIED BIO MATERIALS | 2022年 / 5卷 / 05期

基金：

中国国家自然科学基金;

关键词：

aptamer; selection; liquid biopsy; circulating tumor cells; extracellular vesicles; CIRCULATING TUMOR-CELLS; QUANTITATIVE SCREENING METHOD; HIGHLY EFFICIENT CAPTURE; CANCER-CELLS; HIGH-AFFINITY; DNA APTAMERS; ELECTROCHEMICAL DETECTION; ULTRASENSITIVE CAPTURE; MOLECULAR RECOGNITION; PARTICLE DISPLAY;

D O I：

10.1021/acsabm.1c01202

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Liquid biopsy capable of noninvasive and real-time molecular profiling is considered as a breakthrough technology, endowing an opportunity for precise diagnosis of individual patients. Extracellular vesicles (EVs) and circulating tumor cells (CTCs) consisting of substantial disease-related molecular information play an important role in liquid biopsy. Therefore, it is critically significant to exploit high-performance recognition ligands for efficient isolation and analysis of EVs and CTCs from complex body fluids. Aptamers exhibit extraordinary merits of high specificity and affinity, which are considered as superior recognition ligands for liquid biopsy. In this review, we first summarize recent advanced strategies for the evolution of high-performance aptamers and the construction of various aptamer-based recognition elements. Subsequently, we mainly discuss the isolation and analysis of EVs and CTCs based on the aptamer functioned biomaterials/biointerface. Ultimately, we envision major challenges and future direction of aptamer-based liquid biopsy for clinical utilities.

引用

页码：1954 / 1979

页数：26

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