Medium-dose riboflavin as a prophylactic agent in children with migraine: A preliminary placebo-controlled, randomised, double-blind, cross-over trial

被引:61
作者
Bruijn, Jacques [1 ,2 ]
Duivenvoorden, Hugo [3 ]
Passchier, Jan [3 ,4 ]
Locher, Heiko [2 ]
Dijkstra, Natascha [2 ]
Arts, Willem-Frans [2 ]
机构
[1] Vlietland Hosp, Dept Paediat, NL-3118 JH Schiedam, Netherlands
[2] Sophia Childrens Univ Hosp, Rotterdam, Netherlands
[3] Erasmus MC, Rotterdam, Netherlands
[4] Vrije Univ Amsterdam, Amsterdam, Netherlands
关键词
migraine; tension-type headache; children; riboflavin; randomised trial; RESONANCE-SPECTROSCOPY; ENERGY-METABOLISM; HEADACHE; EFFICACY; BRAIN;
D O I
10.1177/0333102410365106
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Riboflavin seems to have a promising effect on migraine in adults. The present study examines whether riboflavin has a prophylactic effect on migraine in children. Objective: To investigate whether riboflavin in a dosage of 50 mg/day has a prophylactic effect on migraine attacks in young children. Subjects and methods: This randomised, placebo-controlled, double-blind, cross-over trial included 42 children (aged 6-13 years) with migraine of whom 14 children were also suffering from tension-type headache. Following a 4-week baseline period, all children received placebo for 16 weeks then riboflavin for 16 weeks (or vice versa) with a washout period of 4 weeks in between. The primary outcome measure was reduction in mean frequency of migraine attacks and tension-type headache in the last 4 weeks at the end of the riboflavin and placebo phase, compared with the preceding baseline or wash-out period. Secondary outcome measures were mean severity and mean duration of migraine and tension-type headaches in the last 4 weeks at the end of the riboflavin and placebo phase, compared with the preceding baseline or wash-out period. Results: No significant difference in the reduction of mean frequency of migraine attacks in the last month of treatment was found between placebo and riboflavin (P = 0.44). However, a significant difference in reduction of mean frequency of headaches with a tension-type phenotype was found in favour of the riboflavin treatment (P = 0.04). Conclusions: In this group of children with migraine, there is no evidence that 50 mg riboflavin has a prophylactic effect on migraine attacks. We found some evidence that 50 mg riboflavin may have a prophylactic effect on interval headaches that may correspond to mild migraine attacks or tension-type headache attacks in children with migraine.
引用
收藏
页码:1426 / 1434
页数:9
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