Background: Riboflavin seems to have a promising effect on migraine in adults. The present study examines whether riboflavin has a prophylactic effect on migraine in children. Objective: To investigate whether riboflavin in a dosage of 50 mg/day has a prophylactic effect on migraine attacks in young children. Subjects and methods: This randomised, placebo-controlled, double-blind, cross-over trial included 42 children (aged 6-13 years) with migraine of whom 14 children were also suffering from tension-type headache. Following a 4-week baseline period, all children received placebo for 16 weeks then riboflavin for 16 weeks (or vice versa) with a washout period of 4 weeks in between. The primary outcome measure was reduction in mean frequency of migraine attacks and tension-type headache in the last 4 weeks at the end of the riboflavin and placebo phase, compared with the preceding baseline or wash-out period. Secondary outcome measures were mean severity and mean duration of migraine and tension-type headaches in the last 4 weeks at the end of the riboflavin and placebo phase, compared with the preceding baseline or wash-out period. Results: No significant difference in the reduction of mean frequency of migraine attacks in the last month of treatment was found between placebo and riboflavin (P = 0.44). However, a significant difference in reduction of mean frequency of headaches with a tension-type phenotype was found in favour of the riboflavin treatment (P = 0.04). Conclusions: In this group of children with migraine, there is no evidence that 50 mg riboflavin has a prophylactic effect on migraine attacks. We found some evidence that 50 mg riboflavin may have a prophylactic effect on interval headaches that may correspond to mild migraine attacks or tension-type headache attacks in children with migraine.
机构:
Univ Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Di Lorenzo, C.
;
Pierelli, F.
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Univ Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Pierelli, F.
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Coppola, G.
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Bietti Eye Foundation IRCCS, Dept Neurophysiol Vis & Neurophthalmol, Rome, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Coppola, G.
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Grieco, G. S.
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Fdn IRCCS San Raffaele, IRCCS C Mondino Inst Neurol, Mol Genet Lab, Rome, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Grieco, G. S.
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Rengo, C.
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Fdn IRCCS San Raffaele, IRCCS C Mondino Inst Neurol, Mol Genet Lab, Rome, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Rengo, C.
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Ciccolella, M.
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IRCCS Bambino Gesu, Rome, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Ciccolella, M.
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Magis, D.
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Univ Liege, CHR Citadelle, Dept Neurol, Headache Res Unit, Liege, BelgiumUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Magis, D.
;
Bolla, M.
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Univ Liege, CHR Citadelle, Dept Neurol, Headache Res Unit, Liege, Belgium
Univ Ctr Adapt Disorders & Headache, IRCCS Neurol Inst C Mondino, Pavia, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Bolla, M.
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Casali, C.
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Univ Roma La Sapienza, Polo Pontino ICOT, Rehabil Unit, Latina, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Casali, C.
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Santorelli, F. M.
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IRCCS Bambino Gesu, Rome, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Santorelli, F. M.
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Schoenen, J.
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IRCCS INM Neuromed, Headache Clin, Pozzilli, Italy
Univ Liege, CHR Citadelle, Dept Neurol, Headache Res Unit, Liege, BelgiumUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
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Univ Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Di Lorenzo, C.
;
Pierelli, F.
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Univ Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Pierelli, F.
;
Coppola, G.
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机构:
Bietti Eye Foundation IRCCS, Dept Neurophysiol Vis & Neurophthalmol, Rome, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Coppola, G.
;
Grieco, G. S.
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h-index: 0
机构:
Fdn IRCCS San Raffaele, IRCCS C Mondino Inst Neurol, Mol Genet Lab, Rome, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Grieco, G. S.
;
Rengo, C.
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h-index: 0
机构:
Fdn IRCCS San Raffaele, IRCCS C Mondino Inst Neurol, Mol Genet Lab, Rome, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Rengo, C.
;
Ciccolella, M.
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Bambino Gesu, Rome, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Ciccolella, M.
;
Magis, D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Liege, CHR Citadelle, Dept Neurol, Headache Res Unit, Liege, BelgiumUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Magis, D.
;
Bolla, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Liege, CHR Citadelle, Dept Neurol, Headache Res Unit, Liege, Belgium
Univ Ctr Adapt Disorders & Headache, IRCCS Neurol Inst C Mondino, Pavia, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Bolla, M.
;
Casali, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Polo Pontino ICOT, Rehabil Unit, Latina, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Casali, C.
;
Santorelli, F. M.
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Bambino Gesu, Rome, ItalyUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy
Santorelli, F. M.
;
Schoenen, J.
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS INM Neuromed, Headache Clin, Pozzilli, Italy
Univ Liege, CHR Citadelle, Dept Neurol, Headache Res Unit, Liege, BelgiumUniv Roma La Sapienza, Polo Pontino ICOT, Univ Ctr Adapt Disorders & Headache, Latina, Italy