Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function

被引:153
作者
Dai, Xiaozhen [1 ]
Yan, Xiaoqing [2 ]
Wintergerst, Kupper A. [3 ,4 ,5 ]
Cai, Lu [4 ,5 ,6 ]
Keller, Bradley B. [6 ,7 ]
Tan, Yi [4 ,5 ,6 ]
机构
[1] Chengdu Med Coll, Sch Biosci & Technol, Chengdu, Sichuan, Peoples R China
[2] Wenzhou Med Univ, Chinese Amer Res Inst Diabet Complicat, Sch Pharmaceut Sci, Wenzhou, Peoples R China
[3] Univ Louisville, Dept Pediat, Div Endocrinol, Louisville, KY 40292 USA
[4] Wendy Novak Diabet Ctr, Louisville, KY 40202 USA
[5] Univ Louisville, Dept Pediat, Pediat Res Inst, Louisville, KY 40292 USA
[6] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA
[7] Univ Louisville, Kosair Char Pediat Heart Res Program, Cardiovasc Innovat Inst, Louisville, KY 40292 USA
关键词
ENDOTHELIAL PROGENITOR CELLS; TRANSCRIPTION FACTOR NRF2; PATHWAY ACTIVATION; MITOCHONDRIAL DYNAMICS; DOWN-REGULATION; DUAL ROLES; EXPRESSION; INJURY; DIFFERENTIATION; MAINTENANCE;
D O I
10.1016/j.molmed.2019.09.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic cells and functions to induce a broad range of defenses against exogenous and endogenous stresses, including oxidants, xenobiotics, and excessive nutrient/metabolite supply. Because the production and fate of stem cells are often r d by cellular redox and metabolic homeostasis, important roles of Nrf2 have emerged in the regulation of stem cell quiescence, survival, self renewal, proliferation, senescence, and differentiation. In a rapidly advancing field, this review summarizes Nrf2 signaling in the context of stem cell state and function and provides a rationale for Nrf2 as a therapeutic target in stem cell-based regenerative medicine.
引用
收藏
页码:185 / 200
页数:16
相关论文
共 110 条
[1]   Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury [J].
Acharya, Sanket S. ;
Fendler, Wojciech ;
Watson, Jacqueline ;
Hamilton, Abigail ;
Pan, Yunfeng ;
Gaudiano, Emily ;
Moskwa, Patryk ;
Bhanja, Payel ;
Saha, Subhrajit ;
Guha, Chandan ;
Parmar, Kalindi ;
Chowdhury, Dipanjan .
SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (287)
[2]   Nrf2 in health and disease: current and future clinical implications [J].
Al-Sawaf, Othman ;
Clarner, Tim ;
Fragoulis, Athanassios ;
Kan, Yuet Wai ;
Pufe, Thomas ;
Streetz, Konrad ;
Wruck, Christoph Jan .
CLINICAL SCIENCE, 2015, 129 (12) :989-999
[3]   Mesenchymal stromal cell therapy for liver diseases [J].
Alfaifi, Mohammed ;
Eom, Young Woo ;
Newsome, Philip N. ;
Baik, Soon Koo .
JOURNAL OF HEPATOLOGY, 2018, 68 (06) :1272-1285
[4]   Mesenchymal stem cells: immune evasive, not immune privileged [J].
Ankrum, James A. ;
Ong, Joon Faii ;
Karp, Jeffrey M. .
NATURE BIOTECHNOLOGY, 2014, 32 (03) :252-260
[5]   Isolation of putative progenitor endothelial cells for angiogenesis [J].
Asahara, T ;
Murohara, T ;
Sullivan, A ;
Silver, M ;
vanderZee, R ;
Li, T ;
Witzenbichler, B ;
Schatteman, G ;
Isner, JM .
SCIENCE, 1997, 275 (5302) :964-967
[6]   Stem cells and the impact of ROS signaling [J].
Bigarella, Carolina L. ;
Liang, Raymond ;
Ghaffari, Saghi .
DEVELOPMENT, 2014, 141 (22) :4206-4218
[7]   Maintaining Tissue Homeostasis: Dynamic Control of Somatic Stem Cell Activity [J].
Biteau, Benoit ;
Hochmuth, Christine E. ;
Jasper, Heinrich .
CELL STEM CELL, 2011, 9 (05) :402-411
[8]   The redox-sensing gene Nrf2 affects intestinal homeostasis, insecticide resistance, and Zika virus susceptibility in the mosquito Aedes aegypti [J].
Bottino-Rojas, Vanessa ;
Talyuli, Octavio A. C. ;
Carrara, Luana ;
Martins, Ademir J. ;
James, Anthony A. ;
Oliveira, Pedro L. ;
Paiva-Silva, Gabriela O. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (23) :9053-9063
[9]   Nrf2 activation diminishes during adipocyte differentiation of ST2 cells [J].
Chartoumpekis, Dlonysios V. ;
Ziros, Panos G. ;
Sykiotis, Gerasimos P. ;
Zaravinos, Apostolos ;
Psyrogiannis, Agathoklis I. ;
Kyriazopoulou, Venetsana E. ;
Spandidos, Demetrios A. ;
Habeos, Ioannis G. .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2011, 28 (05) :823-828
[10]   NRF2 Activation in Cancer: From DNA to Protein [J].
Cloer, Erica W. ;
Goldfarb, Dennis ;
Schrank, Travis P. ;
Weissman, Bernard E. ;
Major, Michael B. .
CANCER RESEARCH, 2019, 79 (05) :889-898