Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function

被引：153

作者：

Dai, Xiaozhen ^{[1
]}

Yan, Xiaoqing ^{[2
]}

Wintergerst, Kupper A. ^{[3
,4
,5
]}

Cai, Lu ^{[4
,5
,6
]}

Keller, Bradley B. ^{[6
,7
]}

Tan, Yi ^{[4
,5
,6
]}

机构：

[1] Chengdu Med Coll, Sch Biosci & Technol, Chengdu, Sichuan, Peoples R China

[2] Wenzhou Med Univ, Chinese Amer Res Inst Diabet Complicat, Sch Pharmaceut Sci, Wenzhou, Peoples R China

[3] Univ Louisville, Dept Pediat, Div Endocrinol, Louisville, KY 40292 USA

[4] Wendy Novak Diabet Ctr, Louisville, KY 40202 USA

[5] Univ Louisville, Dept Pediat, Pediat Res Inst, Louisville, KY 40292 USA

[6] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA

[7] Univ Louisville, Kosair Char Pediat Heart Res Program, Cardiovasc Innovat Inst, Louisville, KY 40292 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 02期

关键词：

ENDOTHELIAL PROGENITOR CELLS; TRANSCRIPTION FACTOR NRF2; PATHWAY ACTIVATION; MITOCHONDRIAL DYNAMICS; DOWN-REGULATION; DUAL ROLES; EXPRESSION; INJURY; DIFFERENTIATION; MAINTENANCE;

D O I：

10.1016/j.molmed.2019.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic cells and functions to induce a broad range of defenses against exogenous and endogenous stresses, including oxidants, xenobiotics, and excessive nutrient/metabolite supply. Because the production and fate of stem cells are often r d by cellular redox and metabolic homeostasis, important roles of Nrf2 have emerged in the regulation of stem cell quiescence, survival, self renewal, proliferation, senescence, and differentiation. In a rapidly advancing field, this review summarizes Nrf2 signaling in the context of stem cell state and function and provides a rationale for Nrf2 as a therapeutic target in stem cell-based regenerative medicine.

引用

页码：185 / 200

页数：16

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