Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia

被引：61

作者：

Jeon, Yong Duk ^{[1
,2
]}

Jeong, Woo Yong ^{[1
]}

Kim, Moo Hyun ^{[1
]}

Jung, In Young ^{[1
]}

Ahn, Mi Young ^{[1
,2
]}

Ann, Hea Won ^{[1
,2
]}

Ahn, Jin Young ^{[1
,2
]}

Han, Sang Hoon ^{[1
,2
]}

Choi, Jun Yong ^{[1
,2
]}

Song, Young Goo ^{[1
,2
]}

Kim, June Myung ^{[1
,2
]}

Ku, Nam Su ^{[1
,2
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[2] Yonsei Univ, Coll Med, AIDS Res Inst, Seoul, South Korea

来源：

MEDICINE | 2016年 / 95卷 / 31期

关键词：

bacteremia; central venous catheter; mortality; risk factor; Stenotrophomonas maltophilia; BLOOD-STREAM INFECTIONS; CENTRAL VENOUS CATHETER; TRIMETHOPRIM-SULFAMETHOXAZOLE; ATTRIBUTABLE MORTALITY; ANTIMICROBIAL THERAPY; ONCOLOGY PATIENTS; MULTICENTER; HEMATOLOGY;

D O I：

10.1097/MD.0000000000004375

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia. Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality. In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6%. Based on the univariate analysis, hematologic malignancy (P=0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P <0.001) and the removal of a central venous catheter (CVC) (P=0.040) were significantly related to mortality. In the intensive care unit patients, the Acute Physiology and Chronic Health Evaluation II score (P=0.001) also had significance. Based on the multivariate analysis, the SOFA score (odds ratio [OR] =1.323: 95% confidence interval [CI]: 1.159, 1.509; P < 0.001) and removal of the CVC (OR = 0.330; 95% CI: 0.109, 0.996; P-0.049) were independent factors associated with mortality. Our results suggest that removing a CVC may considerably reduce mortality in patients with S. maltophilia bacteremia.

引用

页数：5

共 26 条

[1] Risk factors for mortality among patients with Stenotrophomonas maltophilia bacteremia in Tokyo, Japan, 1996-2009 [J].