The puzzle of quality of life in schizophrenia: putting the pieces together with the FACE-SZ cohort

被引：10

作者：

Ehrminger, Mickael ^{[1
,2
,3
,4
]}

Roux, Paul ^{[1
,2
,3
,4
]}

Urbach, Mathieu ^{[2
,4
]}

Andre, Myrtille ^{[4
,5
]}

Aouizerate, Bruno ^{[4
,6
,7
]}

Berna, Fabrice ^{[4
,8
,9
]}

Bohec, Anne-Lise ^{[4
,10
]}

Capdevielle, Delphine ^{[4
,11
]}

Chereau, Isabelle ^{[4
,12
]}

Clauss, Julie ^{[4
,8
,9
]}

Dubertret, Caroline ^{[4
,13
,14
,15
]}

Dubreucq, Julien ^{[4
,16
]}

Fond, Guillaume ^{[4
,17
,18
]}

Honciuc, Roxana-Mihaela ^{[4
,12
]}

Lancon, Christophe ^{[4
,18
,19
]}

Laouamri, Hakim ^{[4
]}

Leigner, Sylvain ^{[4
,16
]}

Mallet, Jasmina ^{[4
,13
,14
,15
]}

Misdrahi, David ^{[4
,6
,20
]}

Pignon, Baptiste ^{[4
,21
,22
]}

Rey, Romain ^{[4
,10
]}

Schurhoff, Franck ^{[4
,21
,22
]}

Passerieux, Christine ^{[1
,2
,3
,4
]}

Brunet-Gouet, Eric ^{[1
,2
,3
,4
]}

机构：

[1] Univ Paris Saclay UVSQ, Hlth Sci Dept, Lab Clin & Publ Hlth Res Psychol Cognit & Motor D, EA HANDIReSP 4047, Versailles, France

[2] Versailles Hosp, Univ Dept Adult Psychiat & Addictol, Le Chesnay, France

[3] Univ Paris Saclay, INSERM, CESP, PsyDevTeam, Villejuif, France

[4] Fdn Fondamental, Creteil, France

[5] La Colombiere Hosp, Univ Dept Adult Psychiat, Montpellier, France

[6] Charles Perrens Hosp, Dept Adult Psychiat, Bordeaux, France

[7] Univ Bordeaux, Lab Nutr & Integrat Neurobiol, UMR INRA 1286, Bordeaux, France

[8] Univ Hosp Strasbourg, Dept Psychiat, Strasbourg, France

[9] Univ Strasbourg, INSERM U1114, Strasbourg, France

[10] Univ Claude Bernard Lyon 1, Vinatier Hosp, Lyon Ctr Res Neurosci, PSYR2 Team,INSERM U1028,CNRS UMR5292, Bron, France

[11] Univ Montpellier, INSERM, Neuropsychiat Epidemiol & Clin Res, PSNREC, Montpellier, France

[12] Univ Hosp Clermont Ferrand, Dept Psychiat, Clermont Ferrand, France

[13] Louis Mourier Hosp, Dept Psychiat, Colombes, France

[14] Univ Paris 05, Inst Psychiat & Neurosci Paris, INSERM UMR1266, Paris, France

[15] Univ Paris Diderot, Sch Med, Sorbonne Paris Cite, Paris, France

[16] Alpes Isere Hosp, Psychosocial Rehabil Reference Ctr, Grenoble, France

[17] La Concept Univ Hosp, Dept Publ Hlth, Marseille, France

[18] Univ Aix Marseille, Sch Med, EA 3279, Marseille, France

[19] St Marguerite Univ Hosp, Dept Psychiat, Marseille, France

[20] Univ Bordeaux, CNRS UMR INCIA 5287, Bordeaux, France

[21] Mondor Univ Hosp, DHU Pe PSY, Translat Psychiat Team, INSERM U955, Creteil, France

[22] Univ Paris Est, Sch Med, Creteil, France

来源：

PSYCHOLOGICAL MEDICINE | 2022年 / 52卷 / 08期

关键词：

Cognition; mediation analyses; quality of life; structural equation modeling; COGNITIVE DEFICITS; INTERNALIZED STIGMA; SELF-STIGMA; INSIGHT; SYMPTOMS; SCALE; RELIABILITY; VALIDITY; ASSOCIATION; DEPRESSION;

D O I：

10.1017/S0033291720003311

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background The determinants of quality of life (QoL) in schizophrenia are largely debated, mainly due to methodological discrepancies and divergence about the concepts concerned. As most studies have investigated bi- or tri-variate models, a multivariate model accounting for simultaneous potential mediations is necessary to have a comprehensive view of the determinants of QOL. We sought to estimate the associations between cognitive reserve, cognition, functioning, insight, depression, schizophrenic symptoms, and QoL in schizophrenia and their potential mediation relationships. Methods We used structural equation modeling with mediation analyses to test a model based on existing literature in a sample of 776 patients with schizophrenia from the FondaMental Foundation FACE-SZ cohort. Results Our model showed a good fit to the data. We found better functioning to be positively associated with a better QoL, whereas better cognition, better insight, higher levels of depression, and schizophrenic symptoms were associated with a lower QoL in our sample. Cognitive reserve is not directly linked to QoL, but indirectly in a negative manner via cognition. We confirm the negative relationship between cognition and subjective QoL which was previously evidenced by other studies; moreover, this relationship seems to be robust as it survived in our multivariate model. It was not explained by insight as some suggested, thus the mechanism at stake remains to be explained. Conclusion The pathways to subjective QoL in schizophrenia are complex and the determinants largely influence each other. Longitudinal studies are warranted to confirm these cross-sectional findings.

引用

页码：1501 / 1508

页数：8

共 64 条

[1]

Aaronson N K, 1992, Qual Life Res, V1, P349, DOI 10.1007/BF00434949

[2] RELIABILITY AND VALIDITY OF A DEPRESSION RATING-SCALE FOR SCHIZOPHRENICS [J].