Synthesis and properties of a novel bridged nucleic acid with a P3′→N5′ phosphoramidate linkage, 5′-amino-2′,4′-BNA

被引：21

作者：

Obika, S ^{[1
]}

Nakagawa, O ^{[1
]}

Hiroto, A ^{[1
]}

Hari, Y ^{[1
]}

Imanishi, T ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Osaka 5650871, Japan

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 17期

关键词：

D O I：

10.1039/b307290h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

5'-Amino-2', 4'-BNA, a novel analogue of BNA series compounds, was successfully synthesized, and its incorporated oligonucleotides showed potent duplex- and triplex-forming ability and resistance against snake venom phosphodiesterase.

引用

页码：2202 / 2203

页数：2

共 25 条

[1] Re-examination of the intrinsic, dynamic and hydration properties of phosphoramidate DNA [J].

Banavali, NK ;

MacKerell, AD .

NUCLEIC ACIDS RESEARCH, 2001, 29 (15) :3219-3230

[2] SOLID-PHASE SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING PHOSPHORAMIDATE INTERNUCLEOTIDE LINKAGES AND THEIR SPECIFIC CHEMICAL CLEAVAGE [J].

BANNWARTH, W .

HELVETICA CHIMICA ACTA, 1988, 71 (06) :1517-1527

[3] Hydration effects on the duplex stability of phosphoramidate DNA-RNA oligomers [J].

Barsky, D ;

Colvin, ME ;

Zon, G ;

Gryaznov, SM .

NUCLEIC ACIDS RESEARCH, 1997, 25 (04) :830-835

[4] THE SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES BY THE PHOSPHORAMIDITE APPROACH AND THEIR APPLICATIONS [J].

BEAUCAGE, SL ;

IYER, RP .

TETRAHEDRON, 1993, 49 (28) :6123-6194

[5] SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDE N3'-]P5' PHOSPHORAMIDATES [J].

CHEN, JK ;

SCHULTZ, RG ;

LLOYD, DH ;

GRYAZNOV, SM .

NUCLEIC ACIDS RESEARCH, 1995, 23 (14) :2661-2668

[6]

DORONINA SO, 1997, CHEM SOC REV, P63

[7] Oligonucleotide N3′ → P5′ phosphoramidates as potential therapeutic agents [J].

Gryaznov, SM .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1999, 1489 (01) :131-140

[8] RNA mimetics:: oligoribonucleotide N3′→5′ phosphoramidates [J].

Gryaznov, SM ;

Winter, H .

NUCLEIC ACIDS RESEARCH, 1998, 26 (18) :4160-4167

[9] SYNTHESIS AND PROPERTIES OF OLIGONUCLEOTIDES CONTAINING AMINODEOXYTHYMIDINE UNITS [J].

GRYAZNOV, SM ;

LETSINGER, RL .

NUCLEIC ACIDS RESEARCH, 1992, 20 (13) :3403-3409

[10]

GYRAZNOV SM, 1995, P NATL ACAD SCI USA, V92, P5798

← 1 2 3 →