Extracellular calcium sensing and signalling

被引：510

作者：

Hofer, AM

Brown, EM

机构：

[1] Vet Adm Med Ctr W Roxbury, W Roxbury, MA 02132 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Surg, W Roxbury, MA 02132 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 07期

关键词：

D O I：

10.1038/nrm1154

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ca2+ is well established as an intracellular second messenger. However, the molecular identification of a detector for extracellular Ca2+ - the extracellular Ca2+-sensing receptor - has opened up the possibility that Ca2+ might also function as a messenger outside cells. Information about the local extracellular Ca2+ concentration is conveyed to the interior of many cell types through this unique G-protein-coupled receptor. Here, we describe new emerging concepts concerning the signalling function of extracellular Ca2+, with particular emphasis on the extracellular Ca2+-sensing receptor.

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收藏

页码：530 / 538

页数：9

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