Comparison of the possibilities of gas chromatography mass spectrometry and tandem mass spectrometry systems for the analysis of anabolics in biological material

被引：21

作者：

DeBrabander, HF ^{[1
]}

Batjoens, P ^{[1
]}

Courtheyn, D ^{[1
]}

Vercammen, J ^{[1
]}

DeWasch, K ^{[1
]}

机构：

[1] STATE LAB,B-9050 GENTBRUGGE,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 750卷 / 1-2期

关键词：

mass spectrometry; detection; GC; anabolic agents; steroids; boldenone; norethandrolone;

D O I：

10.1016/0021-9673(96)00411-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatographic techniques such as GC-MS play a most important role in modern multi-residue analysis of anabolic steroids. The major difference between GC-MS apparatus from different manufacturers is the way of detection and recording. Most apparatus use selected-ion monitoring (SIM) for the determination of low concentrations. Systems based on ion trap technology record in full-scan to even picogram concentrations using a computer algorithm to compare the most important peaks of the mass spectrum of the unknown to those of the standard. In this investigation the possibilities of ion trap GC-MS and the recently released GCQ MS and MS(2) for the analysis of anabolics in biological material are compared.

引用

页码：105 / 114

页数：10

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