Effects of Neostigmine and Physostigmine on Activity of Na+,K+-ATPase in Various Subdivisions of Rat Brain

被引：2

作者：

Dubrovskii, V. N. ^{[1
]}

Shalabodov, A. D. ^{[1
]}

Belkin, A. V. ^{[1
]}

机构：

[1] Tyumen State Univ, Tyumen, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 166卷 / 01期

关键词：

Na+; K+-ATPase; physostigmine; neostigmine; cholinoreceptor; ACETYLCHOLINE; BINDING;

D O I：

10.1007/s10517-018-4287-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of intramuscular administration of neostigmine and physostigmine on Na+,K+-ATPase activity in various cerebral subdivisions were examined in rats. In CNS and peripheral tissues, both agents rapidly and significantly reduced activity of cholinesterases by 30-50%. The development of intoxication did not change the marker indices of stress reaction. In the cerebral cortex, physostigmine increased Na+,K+-ATPase activity, whereas neostigmine suppressed it. In addition, neostigmine decreased activity of this enzyme in the cerebellum. In contrast, both agents produced no effects on Na+,K+-ATPase activity in the striatum. The data corroborate the view on functional interaction between Na+,K+-ATPase and nicotinic cholinoreceptors in rat cerebral cortex.

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页码：50 / 53

页数：4

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