Direct Aldol Reaction of Trifluoromethyl Ketones with Ketones Catalyzed by Et2Zn and Secondary Amines

被引：13

作者：

Sasaki, Shigeru ^{[1
]}

Kikuchi, Kasumi ^{[1
]}

Yamauchi, Takayasu ^{[1
]}

Higashiyama, Kimio ^{[1
]}

机构：

[1] Hoshi Univ, Inst Med Chem, Shinagawa Ku, Tokyo 1428501, Japan

来源：

SYNLETT | 2011年 / 10期

关键词：

direct aldol reaction; trifluoromethyl ketone; methyl ketone; diethylzinc; secondary amine; TRIFLUOROACETALDEHYDE ETHYL HEMIACETAL; METHYL KETONES; CARBONYL; COMPLEX;

D O I：

10.1055/s-0030-1260560

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct catalytic aldol reaction of trifluoromethyl ketones with ketones has been accomplished. The reaction was achieved in the presence of 10 mol% Et2Zn and N, N'-dimethylethylenediamine at ambient temperature to give the expected aldoltype products in high yields (up to 99%).

引用

页码：1431 / 1434

页数：4

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